Adaptive/Specific Immunity

Question 1

Adaptive Immunity - 2 Mediators

Answer 1

Humoral - Antibody Mediated Immunity
- Involves B Lymphocytes
Cell-mediated Immunity
- Cytotoxic C cells

Question 2

Major Histocompatibility Complex (MHC) - 2 molecular classes

Answer 2

MHC-I - expressed on all nucleated cells
MHC-II - expressed on antigent-presenting cells
Only identical twins have the same MHCs on their cells

Question 3

When do T-cells recognize antigens?

Answer 3

When they are associated with MHC-2 proteins

Question 4

APCs (Antigen Presenting Cells)

Answer 4

Present exogenous antigens with MHC-II

Question 5

APCs present exogenous antigens with MCH-II

Answer 5

1) phagocytosis of bacteria
2) MHC class 2 molecules produced
3) They are presented on surface of phagocyte, binded peptide fragments to MHC-II
4) Insert antigent MHC-II complexes on plasma membrane

Question 6

Adaptive Immune Response

Answer 6

Antigen Presenting Cells (APC)

Question 7

APCS (MHC-II + Antigen)

Answer 7

Interdigitating dendritic cell / “Professional APC”
Macrophage
B lymphocyte (B cell)

Question 8

Antigen Characteristics (2)

Answer 8

Reactivity - Antibody binds to the antigen that provoked it
Immunogenicity - Can provoke an immune response (production of antibody specific to that antigen)