adaptive IS Flashcards
what are the features of adaptive immune system
specific, systematic ( acts on site away from aggression) and has memory ability
what does humoral immunity include
antibody production by B cells ( palms cells)
complement protein which are produced in liver ( soluble in blood and lymph )
what does cell mediated immunity include
B and T lymphocytes
how T cells are activated
primarily in thymus during infancy
describe T cells
exposed to protein antigen
displayed by MHC cells receptors on dendritic cell
endogenous antigens displayed on class…
MHC II
exogenous antigens displayed on class..
MHC I
what are B lymphocytes
plasma cells
immunoglobulins
can perform: neutralisation and angulation
produce antibodies
how is antibody binding diversity is achieved
naive B cells will randomly arrange antibody binding genes
Which will encode variable regions
TdT will add additional nucleotide
Binding site will recognise the pathogen and will be optimised by AIDS ( ransom mutations )
how antigen can be inactivated
by binding of antibody ( agglutination)
by tagging them for destruction
by phagocytosis
tell about IgM
neutralisation
agglutination
produce in primary response ( B cells)
tell about IgA
neutralisation
agglutination
present on mucosal surface
prevent attachment to epithethelial surface
tell about IgD
neutralisation
agglutination
always attached to external surface go B cell, acts as antigen receptor
IgG
neutralisation agglutination crosses placenta most abundant in plasma circulates in blood and lymph main antibody in secondary and late primary response
IgE
neutralisation
agglutination
involved in allergens
binds to mast cells, cause release of histamines
compliment antibodies
processed by liver
work with antibodies
promote cell death
what is immune therapy
production of antibodies artificially to recognise particular cancer cells
