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Skin > Adaptive Immunology > Flashcards

Adaptive Immunology Flashcards

1
Q

IgM

A
  • Produced first
  • sign of acute infection
  • activate classical complement
  • primary BCR
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2
Q

IgD

A
  • BCR

- secreted in upper respiratory mucosa

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3
Q

IgG

A
  • most abundant
  • opsonization
  • ADCC
  • cross placenta
  • activates classical complement
  • 4 subtypes
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4
Q

IgA

A
  • mucosal immunity
  • mono or dimeric
  • 2 subtypes
  • mother’s milk
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5
Q

IgE

A
  • allergy

- helminth defense

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6
Q

Th1 cells secrete

A

IFN-gamma

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7
Q

Th2 cells secrete

A

IL-4, IL-5, IL-13

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8
Q

Th17 cells secrete

A

IL-17 and IL-22

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9
Q

Th1 general function

A

Macrophage-mediated killing of intracellular pathogens

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10
Q

Th2 general function

A

Antibody-mediated immunity to extracellular parasites, asthma/allergy

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11
Q

Th17 general function

A

Immune response to extracellular fungi/bacteria; autoimmunity

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12
Q

Antigen processing of MHCII is of…

A

Extracellular microbes/antigen

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13
Q

Antigen processing of MHCI is of…

A

Intracellular microbe

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14
Q

MHCII

A
  1. ) phagolysosome digestion
  2. ) ER, alpha and beta chains associate with Ii
  3. ) Exocytosis
  4. ) MHCII-Ii to lysosome»digested»CLIP»HLA-DM»high affinity foreign peptide
  5. ) Loaded MHCII to surface»recognized by naive CD4
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15
Q

MHCI

A
  1. ) intracellular microbes produce protein in cytosol of cell
  2. ) ubiquitin»proteasome»peptide
  3. ) to ER via TAP
  4. ) MHCI with TAP via tapasin
  5. ) peptide cleaved by ERAP then bound to MHCI
  6. ) MHCI dissociates and exits via exocytosis to surface»recognized by CD8
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16
Q

MHCI genes

A

HLA-A
HLA-B
HLA-C

17
Q

MHCII genes

A

HLA-DP - alpha and beta
HLA-DQ - one of two alphas and beta
HLA-DR - alpha, beta 1 and 0 or 1 of (3,4,5)

18
Q

Lymphoid tissue homing receptors

A

CCR7 on cells

CCL19/21 ligands in lymph

19
Q

DCs receptors

A

ICAM-1, B7, cytokines for T cell proliferation (IL-2)

20
Q

Multipotent progenitor cells receptors to home to thymus

A

CCR9/CCL25

21
Q

pro-T cell marker

A

CD2+

22
Q

Bone marrow stromal cells secrete…

A

SCF, Kit, IL-7

23
Q

surrogate light chain proteins

A

VpreB, lambda-5

24
Q

B cells home to primary follicle using chemokines…

A

CXCL13, CXCR5

25
Q

Costimulatory molecules for T-cell activation

A

CD28:B7

26
Q

APC secretes these cytokines for Th1 differentiation

A

IFN-gamma, IL-12

27
Q

APCs secrete this cytokine for Th2 differentation

A

IL-4

28
Q

APCs secrete these cytokines for Th17 differentiation

A

IL-1, IL-6, TGF-beta

29
Q

IL-17 induces tissue cells to secrete…

A

TNF, IL-1, IL-6

30
Q

Stem cell marker

A

CD34

31
Q

B cell markers

A

CD10, CD19

32
Q

T cell markers

A

CD2, CD3, CD4, CD8

Skin (9 decks)

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