Adaptive Immunity

Question 1

Antigenicity

Answer 1

Ability to react specifically with antibody of the cell that prod it

Question 2

Immunogenicity

Answer 2

Abiltiy to induce humoral/cell mediated immune response

Question 3

Haptens

Answer 3

Molecules that aren’t immunogens on their own but can react with specific antibodies. (incomplete antigen)

Question 4

Highest conc in plasma.
can cross placenta
Mediates antibody-dependent cellular cytotoxicity
Monomer

Answer 4

IgG (Gamma)

Question 5

Monomer / Dimer
Protects mucosal surface
Secretory component facilitates transpo into secretions
Viruses, bacteria, protozoal parasites like Entamoebal histolytica

Answer 5

IgA (Alpha) (Secretory)

Question 6

First antibody prod by infant
Pentamer
Most efficient in activating component
Freq found in antibodies against blood grp determinants
Bacteriocidal to Gram -ve bacteria

Answer 6

IgM (Mu)

Question 7

Monomer
Mediates Type 1 hypersensitivity
Main host defense against helminth infection
Allergic reaction
On surface of basophils & mast cells

Answer 7

IgE (Epsilon)

Question 8

Monomer
Present in mature B cell membrane
Function unknown

Answer 8

IgD (Delta)

Question 9

Attenuated vaccines

Answer 9

From weakened avirulent mutant strains
Live vaccines

Question 10

Inactivated vaccines

Answer 10

From pathogens killed by heat or chem

Question 11

Subunit vaccines

Answer 11

Uses the antigen portion of pathogen

Question 12

Conjugate vaccines

Answer 12

conjugating bacterial capsular antigens to molecules that stim antibody prod

Question 13

Toxoid vaccines

Answer 13

Inactivated exotoxin

Question 14

DNA vaccines

Answer 14

Gene from pathogen inserted to plasmid. Plasmid inserted to host skin/muscle. Gene directs synthesis of antigen