Adaptive Immune System

Question 1

Components of Adaptive immune system

Answer 1

Question 2

Anatomy of the Acquired Immune System

Answer 2

Question 3

T cell maturation process

Answer 3

Question 4

CD4+ T cell functions

Answer 4

HLA II recognition
Immunoregulation
Multiple subtypes

Question 5

CD4+ T cell subsets

Answer 5

Th1 - help CD8+ T cells and macrophages
Th2 - help B cells (helper T cells)
Th17 - neutrophil recruitment
Treg - FoxP3 +ve

Question 6

CD8+ T cells function

Answer 6

HLA I recognition
Cell killing - perforin, granzymes and Fas ligand
Cytokine secretion - viruses and tumours

Question 7

B cell maturation

Answer 7

Question 8

B cell selection

Answer 8

Question 9

B cell activation

Answer 9

B cell-antigen binding →
1. IgM producing B cell production
2. Germinal centre reaction - dendritic cells → CD4+ T cells → CD40L:CD40
3. Genetic rearrangements - isotype switching and somatic hypermutation
4. Further differentiation - plasma and memory

Question 10

Immunoglobulin structure

Answer 10

Question 11

Antibody function

Answer 11

Fab mediated - identification
Fc mediated - removal