Acute viral hepatitis Flashcards
family of hepB virus
Hepadna virus type 1
genomic components of HBV
SPCX
particulate forms of HBV
tubules spheres intact virions
genotypes of HBV
A-H
HBV genotypes common in ASIA
B and C
HBV Genotype more likely to clear circulating viremia and to achieve HBsAg seroconversion, both spontaneously and in response to antiviral therapy
A
Jeopardy
A
HBV Genotype more likely to clear circulating viremia and to achieve HBsAg seroconversion, both spontaneously and in response to antiviral therapy
HBV genotype associated with rapidly progressive disease and early development of HCC
C
Predictor of development of chronic HBV infection
Persistence of HBeAg in serum beyond the first three months of acute infection
first virologic marker detectable in serum in HBV infection
HbsAg
HbsAg is detectable in serum within _______ weeks of infection
1-12(usually 8-12 weeks)
HbsAg time course
precedes symptoms or enzyme elevation by 2-6 weeks
becomes undetectable 1-2 months after onset of jaundice
Only serologic evidence of current or recent HBV infection during window period
anti Hbc
Recent and remote HBV infections can be distinguished by
class of anti Hbc
IgM: <6 months
Marker of transmission from replicative to non replicative phase
acute hepatitis-like elevation in aminotransferase activity
