Acute Lung Injury/ARDS

Question 1

Abrupt onset of HYPOXEMIA and BILATERAL PULMONARY EDEMA in ABSENCE of cardiac failure

Answer 1

ACUTE LUNG INJURY (ALI)

Question 2

Refers to the SEVERE manifestation of ALI

Answer 2

ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)

Question 3

Histologic manifestation of ALI/ARDS

Answer 3

DIFFUSE ALVEOLAR DAMAGE

Question 4

Give 4 most common causes of ACUTE LUNG INJURY/ARDS

Answer 4

~ Sepsis
~ Diffuse Pulmonary Infections
~ Gastric aspiration
~ Mechanical trauma (Head)

Question 5

MORPHOLOGY OF ALI/ARDS

What are the 3 stages involved in morphology of ARDS/ALI

Answer 5

~ Acute Exudative stage
~ Proliferative/Organizing stage
~ Late fibrotic stage

**EPF

Question 6

MORPHOLOGY OF ALI/ARDS

WHAT STAGE

Micro:
~ Congestion
~ Interstitial and intra-alveolar edema
~ Inflammation
~ Fibrin deposition
~ Diffuse alveolar damage

Answer 6

Acute exudative stage

Question 7

MORPHOLOGY OF ALI/ARDS

WHAT STAGE

~ Proliferation of TYPE 2 PNEUMOCYTES
~ GRANULATION tissue in alveolar walls and spaces

Answer 7

PROLIFERATIVE/ORGANIZING STAGE

Question 8

MORPHOLOGY OF ALI/ARDS

WHAT STAGE

(+) FIBROTIC THICKENING (Scarring of alveolar septa)

Answer 8

LATE FIBROTIC STAGE