Acute Liver Disease

Question 1

Describe the three types of acute liver disease

Answer 1

Lobular Dissarray and apoptosis, coaggulative necrosis and Acute hepatitis with Mallory Bodies

Question 2

Describe Lobular disarray and Apoptosis

Answer 2

Typically caused by HepA and HepE infections. Complete dissarray of lobules, swelling of the cells, macrophage infiltration, lipofuschin present, lymphocyte infiltraton and apoptotic cells (councilman bodies)

Question 3

Describe Coaggulative Necrosis

Answer 3

Is due to paracetamol overdose and will decrease the level of glutathione in the liver and as a result will predispose to coaggulative necrosis. Zone 3 is most sensitive yet 2 can also be affected

Question 4

Describe Acute Hepatitis with Mallory Bodies

Answer 4

Alcohol abuse, neutrophils present, mallory bodies (c shaped) and ballooned hepatocytes, and fibrosis around the central vein and the hepatocytes