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Hematology > Acute Leukemia > Flashcards

Acute Leukemia Flashcards

1
Q

Acute leukemia definition

A

Abnormal accumulation of blast cells in the blood marrow and (usually) in the peripheral blood

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2
Q

Significance

A

May be a hematologic urgency (hyperviscosity, leukostasis, sepsis, DIC)
Usually fatal within months without chemo

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3
Q

Causes

A 
Idiopathic 
Secondary: MDS
Drugs, chemicals: benzene, chemo
Ionizing radiation: incidence 10x 
Viruses: 
HTLV: T-ALL
EBV: Burkitt lymphoma, Hodgkin 
HHV-8: B-cell 
HCV: B-cell

Bacteria: H. pylori
Malaria: Burkitt

Down’s, Fanconi

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4
Q

Acute leukemia characterized

A

ALL: Children, 80% of childhood leukemia
More than 85% curable

AML: mainly adults, 80% adult leukemia

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5
Q

Clinical:

A 
Symtoms due to 
Bone marrow failure 
Tissue infiltration 
Leukostasis 
DIC
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Hematology (5 decks)

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