Acute Kidney Injury

Question 1

Aminoglycoside Toxicity

Answer 1

FENa > 1%

Non-oliguric ATN, granular casts in urine

Serum Cr rises 5-10 days after starting therapy

Question 2

Acute Interstitial Nephritis

Answer 2

Urine findings: leukocytes, erythrocytes, WBC casts

Fever, Maculopapular rash, peripheral eosinophilia, urine eos

Cephalosporins are common cause

Onset 3-5 days after 2nd drug exposure

Question 3

Cholesterol Emboli

Answer 3

Generally after invasive procedure (catheterization) or anticoagulant/thrombolysis administration

Clinical features include rash (livedo reticularis), AKI, purple discoloration of the toes, bowel ischemia, neurologic manifestations, and eosinophilia

Question 4

Contrast induced

Answer 4

increase in serum creatinine of 0.5 mg/dL or an increase in serum creatinine of 25% from baseline at 48 hours after contrast administration.