Acute Kidney Injury Flashcards

1
Q

What is AKI?

A

rapid reduction of GFR → increased nitrogenous waste products

  • +/- Decreased urine output
  • 5-7% of hospitalizations results in AKI
    • 5-10x as many as community AKI
      • critically ill patients may end up with CKD → mortality rate > 50% with AKI
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2
Q

Staging System for AKI

A
  • Stage 1:
    • absolute serum creatinine increase
      • 0.3mg/dL or 150-200% increase from baseline
      • Urine Output: less than 0.5ml/kg/hour for 6+ hours
  • Stage 2:
    • absolute serum creatinine increase (unavailable) or 200-300% increase from baseline
    • Urine Output: less than 0.5ml/kg/hr for 12+ hours
  • Stage 3:
    • absolute serum creatinine increase ≥ 4mg/dL with an acute increase of ≥ 0.5mg/dL or 300% or greater increase from baseline
    • Urine Output: urine output less than 0.3ml/kg/hr for 24 hours or anuria for 12 hours
    • need renal replacement therapy
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3
Q

RIFLE Criteria and AKI

A
  • RIFLE: Risk, Injury, Failure, Loss, ESKD
  • GFR criteria
    • Risk: increase SCr x 1.5 or GFR decrease greater than 25%
    • Injury: increase SCR x 2 or GFR decrease greater than 50%
    • Failure: increase SCr x 3 or GFR decrease greater than 75%
      • OR SCr greater than 4mg/dL, acute ≥ 0.5mg/dL
  • Urine Output Criteria
    • Risk: UO <0.5mL/kg/hour x 6 hours
    • Injury: UO <0.5 mL/kg/hour x 12 hours
    • Failure: UO <0.3mL/kg/hour x 24 hours, or anuria x 12 hours
  • LOSS: persistent AKI - complete loss of kidney function > 4 weeks
  • ESKD: loss of kidney function > 3 months
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4
Q

Cockcroft-Gault Equation For Adults

A
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5
Q

Meds that can cause AKI

A
  • high risk pts should avoid these meds
  • aminoglycosides
  • amphotericin B
  • radiocontrast Dye
  • Cyclosporine and Tacrolimus
  • ACE and ARB
  • NSAIDs
  • MTX etc
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6
Q

Diuretics and AKI

A

they may increase urine output but do not decrease mortality

  • should only be used for hypervolemic states
  • should NOT be used to make oliguric patients nonoliguric in AKI, nor increase urine output when pt is NOT hypervolemic
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7
Q

Loop Diuretics and dosage

A

40mg furosemide = 20 mg torsemide = 1 mg bumetanide

  • torsemide and bumetanide have a greater bioavailability and duration than furosemide
  • 40mg furosemide IV → response in 30min - 1 hour (output ≥ 1mL/kg/hr)
  • can double dose if AKI pt with fluid overload is not initially responsive → if still not responsive then add thiazide
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8
Q

Dopamine & Fenoldopam and AKI

A
  • Dopamine = improves urine output but does not have any clinical benefit
  • fenoldopam = low dose reduces SCr but did not improve mortality or lower the need for dialysis
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9
Q

Fenoldopam (Corlopam)

A

Stimulates dopamine D1-like and Alpha-2 (mild-mod affinity) receptors → causes rapid vasodilation

  • R-isomer = responsible for biological response
  • INDICATIONS: severe HTN
    • contrast induced nephropathy (off-label)
  • SEs:
    • ≥ 5%: flushing, hypotension, headache, nausea
    • <5%: angina, bradycardia,, chestpain, MI, orthostatic hypotension
      • anxiety, dizziness
      • hyperglycemia, hypokalemia
      • abdominal pain, N/V/D Constipation
      • UTIs
      • bleeding, leukocytosis
      • IOP increased
      • BUN and creatinine increase
  • DDI: antihypertensive meds → increases hypotension
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10
Q

Preventing Contrast-Induced Nephropathy

A
  • NS or NAHCO<u>3</u> IV infusion → decreases incidence of nephropathy
    • give 1mL/kg/hr NS IV 12 hours before and 12 hours after procedure
    • if pt high risk for volume overload: CHF with EF <40% → use 3 amps NaHCO3 + 1L D5W
  • N-acetylcysteine:
    • PO at 1200mg Q12 hours
      • for high-risk pts the before contrast and day of procedure
      • AVOID: diuretics, NSAIDs, ACEI, Metform 24-48 hours prior
  • Statins:
    • use before coronary angiography → reduces contrast induced AKI
    • high intensity
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11
Q

Rule of Thumb for Fluid Replacement in adults

A

30-40mL/kg/day + normal insensible losses (lungs: 400mL/day, Skin 400mL/day, Feces 100mL/day)

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12
Q

Drugs that cause HyperK

A

K-sparing diuretics

K-supplements

Abx with K salts

ACE-I

ARBs

NSAIDs

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13
Q

Hypokalemia Tx

A

When to tx? <3.5 mEq/L and/or pt is symptomatic

  • treatment:
    • oral: K-chloride, KPO4, K-acetate, K-citrate, k-gluconate
      • IV: if >10 mEq/L should be monitored via telemetry
    • other: diuretic induced (spironolactone- K+ sparing diuretic)
      • correct hypomagnesemia
        • ****low magnesium makes body resistant to K+ replacement, so tx mg deficiency first or concurrently*****
      • correct acid-base imbalance
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14
Q

Hyperkalemia Tx

A
  • Symptomatic (urgent/emergent)
    • IV calcium to stabilize the heart membrane
    • insulin +/- glucose/dextrose to temporarily push K+ back into the cell
    • albuterol to also temporarily push K+ back into the cell
    • Sodium bicarb to be considered to tx acidosis
    • Eliminate Source: IV, total parenteral nutrition (TPN), tube feeds, oral supplements, K sparing diuretics
  • Symptomatic:
    • sodium polystyrene sulfonate (Kayexelate) → binds potassium, slower onset, but duration of 4-6 hours (constipation though…)
    • Loop diuretics (lasix)
  • Asymptomatic;
    • eliminate source
    • kayexelate (sodium polystyrene sulfonate) → binds potassium
    • loop diuretics
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15
Q

Serum and Ionized/Free Calcium Levels

A
  • Normal Total Serum Ca2+: 8.5-10.5mg/dL
    • >13 or <6 = critical values
  • Normal Ionized/Free Ca2+: 1.18-1.30mmol/L
    • critical values= <0.9 or >1.6
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16
Q

Roles of Calcium and interaction with albumin

A
  • Roles: bone health, nerve transmission, muscle contraction
  • 50% bound to albumin
    • → alkalosis increases binding to albumin
17
Q

Parathyroid Hormone and Ca2+ Regulation

A
  • increased PTH → efflux of calcium from the bones
    • decreased loss of calcium in urine
    • increased release of vitamin D from the kidney
      • → enhanced absorption of calcium from the intestine
18
Q

Hypocalcemia S/Sxs and Causes

A
  • S/sxs: tetany, paresthesia of fingers/toes, cramping, spasms, confusion, hairloss, psoriasis
  • causes: malabsorption
    • vitamin D deficiency
    • deficient PTH
    • hypomagnesia
    • renal failure
      • inadequate hydroxylation of 25-hydroxy vitamin D
    • Drugs: furosemide, Biphosphonates, Phenobarbital → increases metab of vitamin D
      • Phenytoin → increases metab of vitamin D
19
Q

Hypocalcemia and Tx

A

When to tx: corrected serum Ca2+<8.5mg/dL and/or s/sxs and/or Ca2+ x PO4 <55

  • tx underlying condition
  • IV calcium gluconate/calcium chloride
    • Ca-gluconate: 9% elemental Ca2+
    • Ca-Cl: 27% elemental Ca2+
  • Oral Calcium/Vitamin D supplement
    • <18yo → 1200-1500mg/day
    • 18-50 → 1000mg/day
    • >50 yo → 1200-1500 mg/day
20
Q

Phosphorus Normal Levels

A

Normal Serum levels: 2.7-4.6mg/dL

mostly intracellular

70-90% absorbed in jejunum

21
Q

Hyperphosphatemia S/sxs and Causes

A
  • S/sxs: related to development of hypocalcemia secondary to calcium precipitation
  • Causes:
    • ARF/CRF
    • exogenous admmin
    • HypoPTH (decreased Ca2+)
    • Rhabdomyolysis
    • DKA
22
Q

Hyperphosphatemia Tx

A

when to tx: PO4 >9mg/dL and/or Ca2+ x PO4 product ? 55

  • tx: IV calcium
  • dietary restriction
  • calcium salts (Ca-ACE), aluminum salts (AlOH), magnesium salts (MgOH)
  • sevelamer (Renagel) TID with food
  • Lanthanum Carbonate (Fosrenal)
    • cationic polymer
  • sucroferric oxyhydroxide (Velphoro)
    • cationic polymer
  • Ferric Citrate (Auryxia)
    • 1 gm ferric citrate = 210mg ferric iron
    • PO with food
23
Q

When do d/c ACEI in AKI?

A

if AKI is more severe: SCr 1-2 or GFr < 30

24
Q

ACE-I

A

captopril, lisinopril, benzapril, etc. “-pril”

not for GFR <30

good for reducing proteinuria in CKD pts with HTN

25
Q

ARBs

A

losartan, candesartan, valsartan, etc “-sartan”

good for reducing proteinuria in CKD pts with HTN

26
Q

Potassium sparing Diuretics

A

Spironolactone, Triamterene, Amiloride