Acute Inflammation Cellular Event

Question 1

What is leukocyte extravasation

Answer 1

1. margination
2. rolling,
3. adhesion
4. transmigration

Question 2

Chemotaxis

Answer 2

The release of chemicals agents that attracts neutrophils or other leukocytes to the site of injury

Question 3

Chemical mediators of neutrophils

Answer 3

1. arachidonic acid metabolites
2. Vasoactive amines
3. complement system
4. kinin system
5. cytokines system
6. Clotting system

Question 4

Role of arachidonic acid in inflammation and repair

Answer 4

a. prostaglandins– involved in patho of pain and fever

b. leukotrienes– involved in bronchospasms, vasoconstriction, and vascular permeability.

Question 5

Role of vasoactive metabolites in inflammation and repair

Answer 5

released histamine and serotonin
Increase vasodilation and permeability
found in basophils, mast cells and platelets

Question 6

Role of component system in inflammation and repair

Answer 6

increase vascular permeability, vasodilation, leukocyte adhesion, chemotaxis, activation and phagocytosis

found in plasma

Question 7

role of kinin system in inflammation and repair

Answer 7

creates vasoactive peptides

increase permeability, contractions of smooth muscle, vasodilation and pain.

Question 8

Role of cytokines in inflammation and repair

Answer 8

involved in patho of sepsis –fever, loss of appetite, release or corticosteroids and neutrophils.

released by lymphocytes and macrophages

2 types

1. Interlukin 1
2. TNF

Question 9

Role of Clotting factor in inflammation and repair

Answer 9

Thrombin cause development of fibrin= clot

breakdown of fibrin - increases permeability of vessels.