Acute inflammation Flashcards
What occurs when destroy/contain noxious stimulus (actually/potential tissue damaging event)
dilution of toxins
entry of leukocytes (WBC protecting infection)
What occurs when inflammation initiates repair or returns to function
fibrin formation
transport of nutrients
transport of drugs
What can cause acute inflammation
list 5
physical (trauma) chemical (cigarette) infectious (toxins) oxygen deprivation (hypoxia) immunologic (autoimmue)
Two types of vascular events in acute inflammation
vasodilation
permeability
What is exudate and when does it occur
fluid that leaks out of blood vessels (part of healing process)
after vascular and cellular events
What is the cellular event in acute inflammation
chemotaxis
What are the 3 types of exudate
serous
fibrinous
purulent
Cardinal (visual) signs of inflammation
heat redness swelling pain loss of function
What are the 3 possible outcomes of acute inflammation
Resolution
Repair
Chronic inflammation
List 6 functions of acute inflammation
dilution of toxins entry of antibodies fibrin formation delivery of nutrients + oxygen stimulation of the immune response transport of therapeutic drugs
Vascular changes - permeability
inflammatory mediators induce conformational changes in endothelial cells lining venules increasing permeability
Vascular changes - vasodilation (widening of blood vessels)
What attracts to site of inflammation
fluid flow to ……… ………..
Increases …. and movement of fluid contributes to ….. …….. ………..
Leukocytes attract by chemotaxis to site of inflammation
Fluid flow to extra-vascular compartment
Increases BF and movement of fluid contributes to heat, redness and swelling
List 3 Inflammatory exudate cells
neutrophils
monocytes + lymphocytes (later on)
occasional erythrocytes
Definition of pus
what is it rich in
Inflammatory exudate rich in neutrophils, some are dead/dying, through autodigestion in their own enzymes
often contains bacterial debris
