Acute ICU Flashcards

1
Q

Which drug may reduce the duration of delirium in adult ICU patients?

A

Atypical antipsychotics

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2
Q

Risk factors for delirium

A
Preexisting dementia
	History of HTN
	History of alcoholism
	High severity of illness at admission
	Coma
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3
Q

Prevention of delirium

A

Early mobilization (no pharm prevention)

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4
Q

Non-pharm treatment for delirium

A

glasses, low stimulation environment, get rid of unneeded drugs, frequent reorientation (this is where you are, why you’re here etc), make sure they know when it is daytime vs. nighttime.

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5
Q

Important AE for atypical antipsychotics?

A

QTc prolongation

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6
Q

Which sedative has some analgesic properties?

A

Dexmedetomidine (Precedex)

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7
Q

What is the MOA of dexmedetomidine (Precedex)

A

Alpha 2 agonist

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8
Q

What are the 2 most common side effects of dexmedetomidine?

A

Bradycardia and hypotension

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9
Q

Brand name of propofol?

A

Diprivan

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10
Q

Levophed generic name is:

A

Norepenephrin

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11
Q

What are some underlying causes of agitation and sedation?

A

Pain, delirium, hypoxemia, hypoglycemia, withdrawal

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12
Q

what does RASS stand for?

A

Richmond agitation-sedation scale

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13
Q

Midazolam brand name:

A

Versed

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14
Q

Midaxolam MOA

A

GABA-A agoinst

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15
Q

Where is midazolam metabolized?

A

liver (clearance decreases with age or renal/hepatic impairment)

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16
Q

MOA of propofol

A

Binds to multiple receptors in the CNS including GABA-A, gycine, nicotinic and M1 receptors

17
Q

Which drugs have anticonvulsant effects?

A

Propofol, Midazolam.

18
Q

Which allergens are included in Propofol that you need to be aware of?

A

Egg and soy

19
Q

Clinical presentation of propofol infusion syndrome

A

Metabolic acidosis, hyperlipidemia, cardiac dysfunction, rhabdomyolysis, acute renal failure

20
Q

MOA of dexmedetomidine

A

selective Alpha2 receptor agonist

21
Q

What are some pros of precedex?

A

Sedative (but more easily arousable and interactive), minimal respiratory depresion, analgesic/opioid sparing and sympatholytic properties

22
Q

If a patient is on precedex do they need to be on a ventilator?

A

No, because respiratory depression is minimal, but you do need to have an Ambu bag in the room.

23
Q

Which agent has the shortest elimination half life?

A

Dexmedetomidine

24
Q

Lorzapam is formulated with propylene glycol, what is the problem with this?

A

Acidosis with longer durations

25
Q

What are some advantages of analgesic optimization before sedation?

A

decreases mechanical ventilation time and ICU length of stay

26
Q

Generic for Neosynephrine

A

Phenylephrine

27
Q

Phenylephrine works on which receptors?

A

primarily alpha 1

28
Q

First line vasopressor for the treatment of septic shock

A

Norepinephrine (“You absolutely need to know this” - Laswell)

29
Q

What is septic shock?

A

SIRS + infection + refractory to fluids

30
Q

Which vasopressor is most likely to cause arrhythmias? (tachyarrhythmias and tachydisrhythmias)

A

Dopamine (comes in a premixed bag)

31
Q

What does B1 receptor stimulation do?

A

increase myocardial contractility and chronicity

32
Q

What are some dose dependent effects of dopamine?

A

low: vasodilation (renal), medium: increased cardiac contractility and chronotropy, Mild SVR incrase, High: vasoconstrictiond due to alpha 1 mediated vasoconstriciton

33
Q

MOA of norepinemprine?

A

potent alpha 1 agonist and modest b agonist activity

34
Q

WHAT IS THE DRUG OF CHOICE FOR SEPTIC SHOCK!!??

A

Norepinephrine

35
Q

What is another name for vasopressin?

A

Antidiuretic hormone

36
Q

What dose should you not exceed with vasopressin and why

A

.04 units/min (larger doses lead to ischemia)

37
Q

Which vasopressor can cause malignant ventricular arrhythmias?

A

Dobutamine

38
Q

MOA of dobutamine

A

Selective B1-agonist with mild B2 and vascular a1-activity