Acute Hypertensive Crisis Uncontrolled HTN √ Flashcards
What defines hypertensive crisis
> 180 SBP and/or >120 DBP
name 4 cause of HTN Crisis
Clonidine withdraw
Serotonin Syndrome
non-medication adherence
recreational drugs
Do all patients have symptoms?
No patients can be asymptomatic
what are the 4 symptoms of HTN crisis
Confusion/Headache
Blurred Vision
Chest pain
NV
What are 4 signs of organ dmg
Stroke
heart attack, HF, Aortic Dissection
Retinopathy
Renal failure
flow chart of HTN crisis
htn emergency vs urgency
Organ Damage becomes an emergency
What to do with HTN Urgency
Start or up oral therapy
then follow up 2-4 weeks later
What to do with HTN Emergency (No Eclampsia or Aortic Dissection)
Reduce BP below 180/120 but not excceding 25%
then 160/110-100 over the next 2-6 hrs
then normal 24-48hrs
BP goal for preclampsia
Reduce BP to <140 SBP in the first hour
What are the 3 treatment goals for Aortic dissection?
<120 SBP in the first hour
HR to 80-60 bpm
Pain Control
3 Sign and Symptoms of Aortic Dissection
Knife-like pain in either the stomach or chest
Elevated kidney and liver
loss of pulse in extremities
Risk Factors for Aortic Dissection
- Uncontrolled HTN
- Illicit drugs
- Weightlifting
- Trauma
- Genetic conditions
How to treat Aortic Dissection
Esmolol 500mcg/kg bolus then 50mcg/kg/min infusion
Labetalol 20mg bolus then 10mg/HR infusion
why do we use esmolol more often
Esmolol is more on hand while labetalol would need to be compounded
When would I use IV vasodilators in the treatment of Aortic Dissection?
additional BP control
How would I titrate Esmolol
25-50mcg/kg/min every min till at goal
MAX 300mcg/kg/min
How would I titrate Labetalol?
up or down 10-20mg/min every 15 mins till at goal
MAX of 120mg
Esmolol and Labetalol 2 side effect and contraindications
Bradycardia and Hypotension
can worse CHF symptoms
X An Active Airway Disease
caution in HFRef
What meds for Aortic Dissection can we control HR if Esmolol and Labetalol need help
Nicardipine
Clevidipine
Nitroprusside
Nicardipine Titration
Start 2-5mg/hour, T 1-5 mg/hr every 2 mins
MAX 15
Clevidipine Titration
Start 2-4mg/hour, T 2-4mg/hour every 1 mins
MAX 32
Nitroprusside Titration
Start 0.25-.5mcg/kg/min, T 0.25mcg/kg/min every 2 mins
MAX of 3mcg/kg/min
If I need more than 2 days of IV vasodilators can i use Nitroprusside?
No bc of Tachyphylaxis
3 side effects of IV vasodilators?
Hypotension
headache
rebound tachy
What AD to watch out for with Clevidipine
Triglycerdimia
When cant I use Clevidipine?
Soy allergy
When can I not use Nitroprusside
Hepatic and Renal failure due to cyanide toxic
X pregnancy
X ACS
Can you give Nitroprusside to renal/hepatic pts?
yes but need to limit
Preeclampsia signs and symptoms
Headache
chest pain
liver and kidney failure
blurred vison
NV
Follow-up thearpy for Aortic Dissection
Not sure if we have to know this
what is the best drug to treat preeclampsia?
4 mg mag sulfate over 30mins
then 2gm/hr titration
Mag titration?
none can keep giving bolus
MAX safe for levels 4.2-8.4 mg/dL
Mag sulfate Adverse effects
None until you reach >8.4 mag
then watch for respiratory depression, heart attack loss of tendon reflexes
CAUTION in kidneys (still can use just monitor)
Labetalol vs hydralazie for preeclampsia
Labetalol can be used in pt that have an ACS
Hydralazine can be used in pt who have active airway disease and HEFref
Which HTN crisis can you use Hydralazine for
only Preclampsia
Hydralazine 3 ad and 2 cautions
Reflex tach
lupus with >300 grams/day
hypotension symptoms
X ACS
X Aortic Dissection
Hydralazine dose
5-20mg/ 4-8hrs or prn with >120 SBP
Treatment for ACS HTN crisis
IV Nitroglycerin 10-20mcg/min
Nitroglycerin Titration
5-10mcg/min every 5 mins
max 200mcg/min
What do watch out for with IV nitrate 3 things
Tachyphylaxis like Nitroprusside
Rebound Tachycardia
right ventricular infarct
Acute decomposition heart failure HTN crisis Treatment
Nitroprusside 0.25-.5mcg/min
Nitroglycerin 10-20mcg/min
Which drug can we use to treat AKI HTN crisis
CHIL
Clevedipine 2-4 mg/hr
Hydralazine 5-20mg every 4-8 hrs no continuous infusion
IV Nicardipine 2-5mg/hr
Labetalol Bolus 20mg then 10mg/hr