acute analgesics

Question 1

ASA adult dose

Answer 1

325-1000 mg q4-6h

Question 2

ASA max dose

Answer 2

4000mg

Question 3

ibuprofen adult dose

Answer 3

400-600 mg q4-6h

Question 4

ibuprofen adult max dose

Answer 4

2400 mg (or 1200mg if heart problems)

Question 5

ibuprofen child dose

Answer 5

age 2-12: 10mg/kg q6-8h

age >12: 200-400mg q4h

Question 6

ibuprofen child max dose

Answer 6

1200mg

Question 7

what is the safest NSAID for cvs pts

Answer 7

Naproxen

Question 8

flurbiprofen adult

Answer 8

50-100mg q4-6h

Question 9

flurbiprofen max dose

Answer 9

300mg

Question 10

diflunisal adult dose

Answer 10

1000mg stat, then 500mg q12h

Question 11

diflunisal adult max dose

Answer 11

1500mg

Question 12

how often is diflunisal taken per day

Answer 12

twice

Question 13

naproxen adult dose

Answer 13

500/550mg stat, then 250/275mg mg q6-8h

Question 14

naproxen daily max

Answer 14

1375mg

Question 15

ketorolac adult dose

Answer 15

30mg IM stat, then 10mg PO q4-6h

Question 16

ketorolac daily max

Answer 16

40mg PO

Question 17

whats the longest time you can take ketorolac

Answer 17

5 days

Question 18

routes of administration of ketorolac

Answer 18

parental and oral

Question 19

ketoprofen adult dose

Answer 19

25-50mg q6-8h

Question 20

ketoprofen daily max

Answer 20

300mg

Question 21

floctafenine adult dose

Answer 21

200-400mg q6-8h

Question 22

floctafenine daily max

Answer 22

1200mg

Question 23

etodolac adult dose

Answer 23

400mg STAT, then 200-400mg q 6-8h

Question 24

etodolac daily max

Answer 24

1200mg

Question 25

misoprostol MOA

Answer 25

synthetic PG E1 analog

Question 26

misoprostol adult dose

Answer 26

200 micrograms QID

Question 27

is misoprostol prescribed alone?

Answer 27

no, it’s prescribed with ibuprofen for cytoprotection

Question 28

side effects of misoprostol

Answer 28

diarrhea, cannot be given during pregnancy

Question 29

acetaminophen adult dose

Answer 29

1000mg q4h prn pain

Question 30

acetaminophen adult max dose

Answer 30

4000mg

Question 31

acetaminopehn child dose

Answer 31

10-15mg/kg q4-6h

Question 32

acetaminophen child daily max

Answer 32

75 mg/kg

Question 33

name the 5 COX2 inhibitors

Answer 33

• rofecoxib
• celecoxib
• etodolac
• meloxicam
• nimesulide

Question 34

celecoxib comes in what dose of tablets

Answer 34

100mg and 200mg

Question 35

celecoxib dose for RA

Answer 35

200mg/day

Question 36

celecoxib dose for OA

Answer 36

200-400mg

Question 37

celecoxib general dose

Answer 37

200mg BID for pain

Question 38

cannot take celecoxib if you have what allergy

Answer 38

sulfonamide

Question 39

the COX2 inhibitors are how much more selective

Answer 39

5-50 fold

Question 40

NSAID drug interactions

Answer 40

• anti-hypertensive
• lithium
• SSRI
• anti-coagulants
• methotrexate

Question 41

function of PG E1

Answer 41

inflammation and vasodilation, cytoprotection

Question 42

function of PG E2

Answer 42

inflammation, vasodilation, uterine contractions

Question 43

cox2 inhibitors are associated with what heart condition

Answer 43

there is evidence of a predisposition to MI

Question 44

in heart vessels, there is a balance between what?

Answer 44

PG I2 and TxA2

Question 45

in atherosclerosis, what is TxA2 and PG I2 amounts

Answer 45

more TxA2 and PGI2 (in balance)

Question 46

if you have COX2 inhibition, what happens to TxA2 and PG I2

Answer 46

you get less PG I2, and more TxA2 relative to PG I2 => risk of thrombosis

Question 47

what enzyme converts acetaminophen to NAPQI

Answer 47

CYP 2E1

Question 48

what clears NAPQI to a non-toxic metabolite

Answer 48

glutathione (if not enough, you get NAPQI build up)

Question 49

what two ways can acetaminophen be converted to non-toxic metabolites

Answer 49

glucoronidation or sulfation