Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

ASNSW Pharmacology > Action > Flashcards

Action Flashcards

1
Q

Adrenaline : Action

A

Stimulates ALPHA, BETA receptors of sympathetic nervous system

  • ALPHA : peripheral vasoconstriction,
    [+]perfusion pressure to vital organs during cardiac arrest
    [-]capillary permeability
    [+]BP in anaphylaxis
  • BETA1 : [+]myocardial excitability & contractility, tachycardia
  • BETA2: bronchodilation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Amiodarone : Action

A

slows sinus rate
incr refractory period of AV node
decr peripheral vascular resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Aspirin : Action

A

Inhibits platelet aggregation - limits thrombus enlargement in acute ACS

Reduces production of prostaglandins relieving pain and fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Atropine : Action

A

Antagonises parasympathetic effects of acetylcholine on muscarinic receptors:

[+] HR via [+] intrinsic rate of sino-atrial node and conduction through AV node

[-] smooth muscle contraction resulting in pupillary dilation, [-] GIT motility, [-] bladder tone

blocks exocrine gland activity causing [-] salivary, bronchial, gastric and sweat secretions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Benzyl Penicillin : Action

A

Bactericidal: inhibits bacterial cell wall synthesis and causes cytolysis when the bacterium tries to divide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Calcium Gluconate : Action

A

Antagonises the effect of hyperkalaemia on the heart.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Clopidogrel : Action

A
  1. Specific and potent inhibitor of platelet aggregation and limits propagation of the thrombus by selectively inhibiting the binding of ADP to its platelet receptor.
  2. Absorbed from stomach and upper bowel. Begins to inhibit platelet function within 30min.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Compound Sodium Lactate : Action

A
  1. Distributed throughout extracellular fluid space following IV infusion.
  2. ~25% remains in intravascular space for a variable period of time.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Droperidol : Action

A
  1. Marked tranquilisation and sedation
  2. [-] BP due to direct vasodilatory effect and ALPHA block.
  3. Potentiates other CNS depressants: Narcotic analgesics (e.g. Fentanyl) and Benzodiazepines (e.g. Midazolam)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Enoxaparin Sodium : Action

A
  1. Induces sustained release of Tissue Factor pathway inhibitor.
  2. Inhibits Thrombin generation
  3. Inhibits coagulation factors Xa and Thrombin (anticoagulant)
  4. {-} reinfarction and ischaemia complications after lysis of STEMI.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Fentanyl : Action

A
  1. Potent Analgesic

2. Effective for IN use because it is rapidly absorbed across mucous membranes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Fexofenadine : Action

A

Non sedating anti-histamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Frusemide : Action

A

Potent loop diuretic which produces [+] urine output by inhibiting renal sodium reabsorption.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Glucagon : Action

A

Converts liver glycogen to glucose. May not be effective if glycogen is depleted due to starvation or chronic liver disease.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Glucose 10% : Action

A

Principle energy source for body cells especially brain.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Glucose Gel : Action

A

Principle energy source for body cells especially brain.

17
Q

Glyceryl Trinitrate : Action

A
  1. Dilates coronary arteries
  2. Dilates systemic veins and arteries
  3. Decreases preload, afterload and BP
18
Q

Hydrocortisone : Action

A

Glucocorticoid drugs that [-] inflmmation and suppresses immune response.

19
Q

Ibuprofen : Action

A
  1. Inhibition of prostaglandin synthesis which is important in the mediation of pain, fever and inflammation
  2. Anti-inflammatory and analgesic effects well suited to musculoskeletal injuries
20
Q

Influenza Vaccine : Action

A

Induces antibodies against the surface antigens of the influenza virus

21
Q

Ipratropium Bromide : Action

A
  1. (Synthetic derivative of Atropine) mAChR antagonist : blocks vagal reflexes mediating broncho-constriction -> Bronchodilator
  2. Synergistic with Salbutamol
22
Q

Ketamine : Action

A
  1. Dissociates CNS from painful stimuli.
  2. Low doses cause a trance-like state characterised by analgesia and amnesia with retention of proactive airway reflexes, spontaneous respirations and cardiovascular activity.
23
Q

Lignocaine : Action

A

Blocks fast sodium channels [-] ventricular excitability and pain transmission

24
Q

Methoxyflurane : Action

A

CNS depressant

25
Q

Metoclopramide : Action

A

Dopamine antagonist (central)

26
Q

Midazolam : Action

A

Anticonvulsant with anxiolytic and amnesic effects

27
Q

Morphine : Action

A
  1. [-] pain perception and anxiety

2. Peripheral vasodilation

28
Q

Naloxone : Action

A

Reverses symptoms caused by opioid analgesics: respiratory depression, sedation, hypotension

29
Q

Ondansetron : Action

A

5-HT3 receptor antagonist (central and peripheral)

30
Q

Oxygen : Action

A

Essential for aerobic metabolic needs and sustaining life

31
Q

Oxytocin : Action

A
  1. Stimulates receptors in the uterus to cause muscle fibres to contract
  2. When given after birth this stimulation causes contractions that shorten the time of the 3rd stage of labour and [-] risk of postpartum haemorrhage. Contractions help detach the placenta from the uterine wall and continued contraction of uterine fibres help expel any blood or clots in the uterine cavity.
  3. Postpartum hhg : main aim is to [+] contractions to minimise blood loss.
32
Q

Paracetamol : Action

A

Temporary relief of pain and discomfort from arthritis, headache, muscular and neuralgic conditions and [-] fever.

33
Q

Pralidoxime Chloride / Atropine : Action

A
  1. Competitive mAChR antagonist on smooth muscle, cardiac muscle and secretory glands and in peripheral autonomic ganglia and CNS : blocks effects of organophosphate poisoning
  2. Pralidoxime reactivates AChE which has been inactivated by phosphorylation due to an organophosphate nerve agent or insecticide.
34
Q

Salbutamol : Action

A

BETA2 agonist in bronchial smooth muscle : bronchodilation

35
Q

Sodium Bicarbonate : Action

A
  1. Reverses metabolic acidosis by buffering H+ ions
  2. [-] plasma Potassium by altering pH an causing intracellular movement of K+ ions.
  3. Alters protein binding of tricyclics by acting on trans-membrane sodium channels.
36
Q

Tenecteplase : Action

A
  1. Dissolves coronary artery thrombi facilitating myocardial reperfusion
  2. Activates fibrinolytic system to degrade the fibrin matrix of a thrombus.

ASNSW Pharmacology (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions