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Dermatology > Actinic Keratosis > Flashcards

Actinic Keratosis Flashcards

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Dermatology Board Prep flashcards
1
Q

UVA

A

can penetrate the dermis and increases level of ROS that indirectly induce DNA mutagenesis

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2
Q

UVB

A

can cuase direct damage to DNA and reach the epidermis
cause tanning

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3
Q

UVC

A

absorbed by the ozone, therefore although it is highly bioactive, terrestrial organisms are not exposed to significant levels of UVC

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4
Q

What are the effects of UVB

A

increase melanocytes
sunburn
inflammation
direct DNA damage
eye damage
skin cancer

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5
Q

What are the effects of UVA

A

premature aging
indirect DNA damage
oxidative stress
skin cancer

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6
Q

Which UV penetrates the dermis?
a. UVB
b. UVA
c. UVC

A

UVA

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7
Q

Which UV penetrates the epidermis?
a. UVB
b. UVA
c. UVC

A

UVB

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8
Q

Actinic kertosis

A

Abnormal keratinocytes are confined to the epidermis and constitute a premalignant change.

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9
Q

actinic keratosis population

A

caucasians, southwestern US, frequent outdoor activity

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10
Q

actinic keratosis pathophysiology

A

years of sun exposure, ultraviolet radiation-induced damage to keratinocyte DNA, abnormal replication occurs abnormal epidermal cellular hyperplasia, arsenic

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11
Q

actinic keratosis PE

A

3-10 mm
Area of increased vascularity
Ill-marginated macules and papules

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12
Q

actinic keratosis dx

A

Shave biopsy
Punch biopsy

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13
Q

Actinic Keratosis sx

A

Single or scattered discrete lesions
Rough, tan-brown, red or skin-colored papules on the face, arms, and hands
Hyperkeratosis

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14
Q

Actinic Keratosis complications

A

Precursor to squamous cell carcinoma
* Induration, inflammation, and oozing
Basal cell carcinoma

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15
Q

Actinic Keratosis tx

A

Sunscreen
Clothing or hats
Limit sun exposure
Anti-inflammatory diet: Vit A derivatives, carotenoids, lutein, b-carotene, lycopene, polyphenols
Watch and wait
Cryotherapy for a few lesions
Excision
Electrodesiccation and curettage
Chemical peels
Diclofenac 3% twice daily for 60-90 days
Imiquimod 5% twice weekly for 16 weeks
Laser
Radiosurgery
Imiquimod 2.5-5%
Solaraze gel
Tretinoin
* Mild actinic damage
* Once day for up 2-4 months
5-fluorouracil .5-5% cream twice daily for 2-4 weeks
* AKs become painful, crusted and eroded, at which time the medication is stopped
* Inhibits DNA synthesis by blocking the enzyme thymidylate synthetase.
* Can cause pain
* Allergic reactions possible
Photodynamic therapy with Topical 5-aminolevulinic acid for 1,000 seconds on next day

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16
Q

Actinic Keratosis ddx

A

Seborrheic keratosis
Bowen’s disease
Squamous cell carcinoma
Superficial basal cell carcinoma

17
Q
A

Actinic Keratosis

Dermatology (11 decks)

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