ACT Cardiovascular Flashcards

1
Q

Investigation of suspected Acute Coronary Syndrome

A

A to E
B - CXR ?cardiomegaly ?pulmonary oedema
C - ECG then continuous cardiac monitoring
Troponin - Take at 3h and 6-12h
FBC – anaemia, inflammation (?pericarditis)
U&Es – Potassium
Glucose – DM, ensure BM kept low (improves outcomes)
Lipids – optimise statin therapy
TFT – cause of arrhythmias

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2
Q

Immediate management of Acute Coronary Syndrome

A
Risk - TIMI for STEMI, GRACE for NSTEMI
Oxygen? only if sats <95%
Morphine + Metoclopramide 10mg
Aspirin 300mg dispersed in water
Nitrates - 2 GTN sprays sublingual 
Ticagrelor 180mg or Clopidogrel 300mg 

PCI or Fondaparinux

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3
Q

Long term management of Acute Coronary Syndrome

A

Patient education
Smoking cessation, Alcohol reduction
Weight loss if overweight
Diet - less fat, sugar, salt. More vegetable
Exercise - Cardiac rehab
DVLA - 4 weeks (Grade 2 = 6 weeks + assessment)

ACEi - Ramipril up to 10mg
B-blocker - Bisoprolol up to 10mg
Cholesterol - Atorvastatin 80mg Nocte
Dual antiplatelet -  Aspirin 75mg 
- Clopidogrel 75mg for 1 year 
Echocardiogram - follow up with cardiology
Follow up GP for bloods +
Influenza immunisation annually 
Manage comorbidities - DM
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4
Q

Investigations for acute ventricular failure

A
A to E
B - ABG + CXR - Alveolar oedema, Kerley B lines, Cardiomegaly, Dilated upper lobe vessels, Pleural Effusion
C - ECG
Bloods: BNP + Troponin
FBC - exclude anaemia 
U&amp;Es - check renal perfusion
TFTs - cause of arrhythmia 
lipids - optimise 
glucose - optimise
Echocardiogram within 48hrs
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5
Q

Immediate management of Acute Ventricular Failure

A
Position - sit up
Oxygen - 
Diuretics - Furosemide 40-80mg IV
Morphine - 5mg
Antiemetic - Metoclopramide 10mg
Nitrates - 2 GTN sprays sublingual
Fluid balance - restriction + daily weights
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6
Q

Assessment of suspected Chronic heart failure

A
Arrange admission if severe symptoms 
If previous MI - urgent 2 week referral 
No previous MI - measure BNP
BNP > 400 pg/mL = Urgent 2 week referral
BNP 100-400 pg/mL = 6 week referral 
BNP < 100 pg/mL = Heart failure unlikely
ECG for all patients 
Consider other tests for causes or differentials
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7
Q

Management of chronic heart failure with reduced ejection fraction

A

Patient education, Screen mental health
Smoking cessation,
Low salt diet
Supervised exercise programme

Furosemide when symptomatic
1st ACEi + Bisoprolol one at a time
Refer if symptoms aren't controlled
Consider Statin + Aspirin if CAD
pneumococcal + annual influenza vaccine

Cardiac resynchronise therapy

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8
Q

Assessment of suspected stable angina

A

Clinical diagnosis based on Hx
ECG - may or may not have evidence of ischaemia
Manage stable angina in Primary care
Refer to a cardiologist for angiography if:
- evidence of extensive ischaemia on ECG
- Angina persists despite optimal drug treatment and lifestyle interventions.
Admit to hospital if unstable angina

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9
Q

Management of stable angina

A

Patient eduction, Screen mental health
Smoking cessation, Alcohol reduction
Diet, Exercise

GTN + Atorvastatin 80mg + Aspirin 75mg
1st: Betablocker or CCB
2nd: Dual therapy with BB and CCB
if CI then a long-acting nitrate, ivabradine, nicorandil

If pain persists despite medical management
Percutaneous Coronary Intervention
Coronary Artery Bipass Graft

Review every 6/12 or 1yr

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10
Q

Management of new Atrial Fibrillation

A
  1. Rate or Rhythm control?
    Rhythm: if new onset, reversible cause, if worsening HF
    Amidoarone -> Electrocardioversion
    ?Prophylaxis with 1st: Bisoprolol
    Rate: 1st Bisoprolol
    2nd Diltizem if active, Digoxin if sedentary
  2. Anticoagulation + Risk factors
    CHA2DS2 VASc - risk of stroke
    HAS-BLED - risk of bleeding
    Apixaban or Warfarin life long
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11
Q

Aetiology of Atrial Fibrillation

A

Ischaemic heart disease
Hypertension
Thyrotoxicosis

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12
Q

Signs, description and aetiology of aortic stenosis

A

Slow rising pulse
Low volume pulse with low pulse pressure
JVP not elevated
Apex beat forceful but not displaced (pressure overload)
Ejection systolic murmur - carotid radiation

Narrowing of the valve orifice due to fusion of the commissures, causes pressure overload in the left ventricle

Degenerative calcification of normal valve
Congenitally bicuspid valve with degenerative changes
Rheumatic heart disease

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13
Q

Causes of pressure overload on the left ventricle

A

Hypertension
Aortic stenosis
Coarctation of the aorta
Hypertrophic cardiomyopathy with subvalvular stenosis

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14
Q

Management of aortic stenosis

A

Symptoms guide to severity
Valve replacement

Transcatheter aortic valve insertion (TAVI)
if unfit for cardiopulmonary bypass

Manage comorbidities

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15
Q

Describe aortic sclerosis

A

Normal pulse and normal apex beat.

An ejection systolic murmur heart loudest over the aortic area with no carotid radiation.

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16
Q

Signs and causes of mitral regurgitation

A

Apex beat usually displaced (volume overload)
Pansystolic murmur radiates to axilla

Leaflet: Congenital, Endocarditis, Degenerative
Papillary muscles + Chordae: MV prolapse, ACS, Marfans
Annular dilation: cardiomyopathy, IHD with HF

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17
Q

Describe rheumatic heart disease

A

Preceding Group A beta haemolytic throat infection followed 2-4 weeks later by acute rheumatic fever.
Antibodies to strep M protein cross react with heart, joints and brain due to molecular mimicry
Chronic rheumatic heart disease causes leaflet thickening and fusion of commissures, lead to

18
Q

Signs of causes mitral stenosis

A

Malar flush - Pulmonary artery hypertension
Atrial fibrillation - 75%
JVP not raised until late
Apex beat not displaced
Apex beat tapping in quality - palpable 1st heart sound
Mitral stenosis = LUB de-derrr
Loud S1 - high left atrial pressure keeps value open until late diastole, systole then slams it shut.
Mid diastolic murmur - rubbing
CXR - Left atrial enlargement

Rheumatic fever
Congenital

19
Q

Management of mitral stenosis

A

Mild: Medical - anticoagulants, diuretics, rate control AF
Moderate: ? Trans-septal valvuloplasty
Severe: Valve replacement

20
Q

Signs and causes of Aortic regurgitation

A
Collapsing water hammer pulse 
Collapsing neck pulse (Corrigans sign)
JVP not raised
Apex beat displaced (Overload) 
Diastolic murmur follows S2
Aortic regurgitation = Lub taaarr
Rheumatic heart disease
Endocarditis
Ankylosing spondylitis
Leutic heart disease
Marfans syndrome
21
Q

Complications of a heart valve replacement

A

POSH Valve

Paravalvular leak - loosening of value stent
Obstruction - by thrombus
Subacute bacterial endocarditis 
Haemolysis due to turbulence
Valve failure
22
Q

What is the New York Heart Association grading of heart failure and angina?

A
1 = No symptoms, or only on exertion 
2 = Symptoms during ordinary physical activity 
3 = Symptoms on less that ordinary activity 
4 = Symptoms at rest
23
Q

Management of tachycardia with adverse features

A

Synchronised Direct Current shock
- up to 3 times

Amiodarone 300mg IV over 10-20mins
- repeat shock
Amiodarone 900mg over 24hrs

24
Q

Management of tachycardia with no adverse features and regular narrow QRS complex

A
Vagal manoeuvres 
Continuous ECG monitoring 
Adenosine 6mg IV bolus 
Adenonise 12mg 
Adenosine 12mg

If rhythm restored = re-entrant paroxysmal SVT
Record normal ECG,
consider antiarhythmic prophylaxis eg.

If rhythm not restored = Seek expert help
Possible atrial flutter - control rate

25
Q

Management of tachycardia with no adverse features and regular broad QRS complex

A

If Ventricular tachycardia:
Amiodarone 300mg IV over 20-60mins
Amiodarone 900mg over 24hrs

If previously confirmed SVT with BBB:
Adenosine 6mg - 12mg - 12mg
As for regular narrow complex tachycardia

26
Q

Management of tachycardia with no adverse features and irrregular broad QRS complex

A

AF with BBB - treat as narrow complex

Pre excited AF - consider amiodarone

Polymorphic VT: eg. Torsade de point
- Magnesium 2g IV over 10mins

27
Q

What are considered adverse features in tachycardia and Bradycardia?

A

Shock
Syncope
Myocardial ischaemia
Heart failure

28
Q

In bradycardia without adverse features, what factors make a patient at risk of asystole

A

Recent asystole
Mobitz type II AV block
Complete heart block with broad QRS
Ventricular pause > 3 seconds

29
Q

Management of bradycardia with adverse features

A

Atropine 500micrograms IV bolus

If resolved - are they at risk of asystole?
Yes = Observe

No = Atropine 500micrograms IV bolus
- repeat to maximum of 3mg 
Isoprenaline 5 micrograms/min IV
Adrenaline 2-10 micrograms/min IV
Or Transcutaneous pacing 
SEEK EXPERT HELP
Arrange Transvenous pacing
30
Q

What defines postural hypotension and what are its causes?

A

A drop of 20/10 mmHg after 1 and within 3 minutes of standing after 10 minutes of supine resting

Elderly - impaired vasomotor reflects
Drugs - antihypertensives, sedatives
Cardiac - aortic stenosis 
Neuro - autonomic neuropathy, parkinson's 
Endocrine - Addisons
31
Q

Management of postural hypertension

A
Treat cause + general advice 
Drink 1.5-2L of fluid a day
Avoid excess alcohol 
More salt in diet if not CI
Sit for 5 minutes before standing from supine
Compression stockings
Performing calf exercises
32
Q

What tool is used to assess cardiovascular risk for primary prevention?

A

QRISK2 = 10 year risk of developing CVD
< 10% = Lifestyle advice to modify risk factors
> 10% = Lifestyle advice + Atorvastatin 20mg
Consider medical modification of other risk factors

33
Q

When should statins be prescribed for primary prevention of CVD?

A

Atorvastatin 20mg should be considered in:

  • QRISK2 of 10% or more
  • Hypercholesterolaemia
  • 85+ years if appropriate
  • T1DM if over 40yr or had T1DM for 10yr+
  • All CKD stage 3 or worse (eGFR 60)
34
Q

Causes of acute left ventricular failure

A

CHAMP

Coronary syndrome
Hypertensive emergency 
Arrhythmia 
Mechanical - valve leak
Pulmonary embolus
35
Q

What are the Major and Minor criteria for diagnosing infective endocarditis?

A

2 Major, or 1 Major + 3 minor, or 5 minor

Duke’s Major criteria:

  • Two separate positive blood cultures > 12hrs apart
  • Clear evidence of endocardial involvement on Echo

Duke’s minor criteria:

  • positive blood culture but not major criteria
  • Echocardiogram signs but not clear
  • Predisposing risk factors
  • Fever > 38.0’C
  • Vascular phenomenon - Janeway lesions, splinter hem
  • Immunological phenomenon - Osler’s nodes, Roth spots
36
Q

Investigation of suspected infective endocarditis

A

Urinalysis – microscopic haematuria
ECG - long PR
Fundoscopy - Roth spots

Three blood cultures - different times within 24 hours, from different sites
FBC - normocytic anaemia, neutrophilia
ESR/CRP - raised

CXR - cardiomegaly
Echocardiogram - transoesophageal more sensitive

37
Q

Management of infective endocarditis

A

Urgent cardiology review with micro input
Abx as per guidelines, empirical then focus
- IV Amoxicillin and Gentamicin for 6/52
Consider surgery - abscess, focal valve lesion

38
Q

Six Ps of acute ischaemic limb

A
Pale
Painful
Pulseless
Perishingly cold
Parasthesia
Paralysis
39
Q

Assessment and investigation of suspected acute limb ischaemia

A

Pain worse on raising limb
Doppler to help identify reduced/absent pulse
Bloods – FBC, U&Es (AKI), CK (muscle ischaemia), Clotting (cause), G&S
Angiography – show obstruction
R/V by senior surgeon

40
Q

Management of acute limb ischaemia

A

Oxygen 15L
Analgesia – morphine
IV access and fluids (if dry) – cell death can cause hyperkalaemia and CK, keep fluids running to prevent AKI

Rx = Embolectomy (Fogarty)/Intra-arterial thrombolysis/Bypass/Amputation
LMWH before/after procedure
– can reduce thrombus developing
Beware: post-op reperfusion and compartment syndrome

41
Q

What is the management of a suspected DVT

A

Wells sc􏰇ore 1 or 0 = do D-Dimer
–ve = DVT unlikely, consider alternative Dx
+ve = Arrange Doppler ultrasonography (USS)

Wells s􏰇cor􏰄e 􏰀2+􏰋 = arrange USS
if imaging delay will be > 4h = start LMWH

If -ve USS but high risk and +ve D-dimer = repeat USS in 6-8 days

+ve USS = Start LMWH immediately and warfarin with 24hrs. Bridge for at least 5 days or INR is above 2.0 for 24hrs, whichever is longer.
Review Warfarin at 3 months

42
Q

What criteria are in the DVT wells score

A
Active cancer (ongoing, within 6 months, or palliative) = 1
Paralysis, paresis or recent plaster immobilisation of the lower extremities = 1
Recently bedridden for 3+ days or major surgery within 12 weeks requiring general or regional anaesthesia = 1
Localised tenderness along the distribution of the deep venous system = 1
Entire leg swollen = 1
Calf swelling 3cm+ larger than asymptomatic side = 1
Pitting oedema confined to the symptomatic leg = 1
Collateral superficial veins (non-varicose) = 1
Previously documented DVT = 1
An alternative diagnosis is at least as likely as DVT = -2