ACS pt 1 Flashcards

rogers

1
Q

what is the definition of ACS?

A

acute myocardial ischemia resulting from an imbalance between myocardial oxygen demand and supply

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2
Q

why is dangerous if a clot forms higher up in the heart?

A

it can lead to more tissue damage downstream

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3
Q

what are the steps of formation of an ischemia?

A

rupture of atherosclerotic plaque
platelet adherence, activation, aggregation, and activation of clotting cascade
fibrin and platelets form clot
ischemia

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4
Q

what is the median age of ACS?

A

68 years

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5
Q

what is the ratio of males to females for ACS?

A

3:2

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6
Q

for the 12 million pts who are hospitalized, how many are NSTEMI and how may are STEMI?

A

70% NSTEMI
30% STEMI

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7
Q

what are the risk factors of ACS?

A

older age
male
positive family history of CAD
presence of peripheral arterial disease
DM
renal insufficiency
prior MI
smoking

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8
Q

what are precipitating factors?

A

recent exercise
weather
diet (large meal)
emotions
coitus
walking against the wind
smoking

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9
Q

how does retrosternal chest pain present?

A

may radiate to shoulder, down the left arm, to the back, or to the jaw
most often at rest

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10
Q

what are other signs and symptoms?

A

NV
diaphoresis
SOB

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11
Q

what are atypical symptoms?

A

epigastric pain
indigestion
stabbing or pleuritic pain
increasing COB in absence of chest pain

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12
Q

what populations are more likely to experience atypical symptoms?

A

elderly
females
diabetics
impaired renal function
dementia

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13
Q

what high risk features would warrant a transportation to emergency medical services?

A

continuing chest pain
severe dyspnea
syncope/presyncope
palpitations

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14
Q

after 10 minutes of arriving to emergency facility, what should all pts with acute chest pain have done?

A

12-lead ECG

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15
Q

what do the QRS waves signal?

A

ventricle contraction

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16
Q

what does the T wave signal?

A

ventricle relaxation

17
Q

what does ST mean?

A

time from S to T
from contraction to relaxation

18
Q

what is the main characteristics of a STEMI on an ECG?

A

persistent ST elevation

19
Q

how does the Q wave change in a STEMI on an ECG?

A

often not present on initial ECG, but develops over hours to day

20
Q

what does the ECG look like for an NSTEMI and UA?

A

may have normal ECG
sometimes have ST depression, transient ST-elevation, or new T-wave inversion
Q changes unlikely
no ST elevation

21
Q

what should be measured asap after presentation to ED with acute CP and suspected ACS?

22
Q

where does troponin originate from?

A

released from necrotic myocytes (injured heart cells) into the blood stream

23
Q

what troponin test prefered?

A

high sensitivity

24
Q

what are the normal levels of troponin in a high sensitivity test?

A

under 14 ng/L

25
what are the benefits of using high sensitivity?
greater sensitivity and negative predictive values shorter time from onset of chest pain to a detectable concentration
26
what is the normal value for conventional troponin?
under 0.05 ng/mL
27
when should troponin be checked and why?
repeat every 3-6 hours for the next 12 hours to identify a rising and/or falling pattern
28
what are the unique characteristics of stable angina compared to UA?
chest pain occurs during physical exertion - predictable - relieved by rest - lasts a short time (under 5min)
29
what are the unique characteristics of UA compared to SA?
chest pain may occur at rest, while sleeping, or with little physical exertion - comes as a suprise - more severe and last longer than stable angina (over 30min)
30
what is the unique characteristic of UA compared to NSTEMI?
less ischemia does not lead to detectable quantities of troponin
31
what is the unique characteristic of NSTEMI compared to UA?
troponin is elevated
32
what is the main difference between NSTEMI and STEMI?
ST elevation (yes STEMI, no NSTEMI)
33
what are complications of ACS?
HF valvular dysfunction arrhythmias bradycardia/heart block pericarditis stroke secondary to LV thrombus cardiogenic shock death
34
what is ventricular remodeling?
changes in the size, shape, and function of the left ventricle after an ACS
35
why does ventricular remodeling occur?
could be related to activation of the renin-angiotensin-aldosterone system OR hemodynamic factors (increased preload/afterload)
36
why is ventricular remodeling a therapeutic goal?
could lead to HF associated with increase morbidity and mortality
37
what is a MACE?
major adverse cardiac event usually includes stroke, MI, cardiovascular death