Acquired Diseases

Question 1

Causes of pericardial effusion in cats based on JAHAA 2008

Answer 1

Hypertrophic cardiomyopathy Neoplasia
Feline infectious peritonitis Unclassified cardiomyopathy Systemic infection
Primary mitral valve disease
Dilated cardiomyopathy
Pericarditis
Disseminated intravascular coagulation Trauma
Peritoneopericardial diaphragmatic hernia Chronic renal failure
Hypoalbuminemia
Pulmonic stenosis
Myocardial necrosis

Question 2

What happens to fatty acids, mitochondria, and ATP. Where does creatine kinase come in?

Answer 2

With HF, energy needs fall short resulting in a substrate switch from fatty acids to carbohydrates and a decrease in aerobic ATP production due to decreased rate of production by mitochondria. HF results in declining levels of creatine phosphokinase in cytoskletons and mitochondria with reduced CPK/ATP ratio. Ex. DCM- decreased expression and mRNA for glycolysis, oxidants enzymes. Mitochondria become smaller but more abundant.

Question 3

Pro-BNP to NT-proBNP enzymes

Answer 3

Corin-myocardium

Furin- serum and other tissues

Question 4

NPR-A functions?

Answer 4

cGMP stim to induce diuresis and natiuresis by inhibiting tubular sodium transport in collecting ducts. Also mediates vasodilation to decrease systemic and pulmonary vascular resistance. And inhibits renin and aldosterone release

Question 5

Clearance of BNPs?

Answer 5

1. NPR-C uptake receptor for internalization and Lysosomal degradation.
2. Membrane bound neutral endopeptidases which cleaves them into inactive fragments.

Question 6

Adrenomedullin

Answer 6

Synthesized by kidney, heart, lungs, adrenal , medulla. Vasodilator

Question 7

Genes and detection of boxer Cm

Answer 7

Desmosomes, Striatin
TDI and TAPSE not helpful
SAECG shows increase in late potentials