Acne Flashcards

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1
Q

clinical features

A
  • pastules
  • papules (raised lumps <1cm)
  • comeodones - HALLMARK

Ina sebacous gland distribution

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2
Q

Aetiology

A

three pathogenic factors

  1. Seborrhoea
  • sebacous glands targets of androgens
  • excessive sensitivity of sebacous eng organs to androgens
  1. Sebum retention
  • hyperkeratinisation of infra infundibulum of sebanous duct
  • many factors particularly chemical composition of sebum in acne and androgens responsible
  1. inflammation
    * inflammatory role of numerous enzymes of proprioni bacterium acnes
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3
Q

Grading system of acne

A

leeds

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4
Q

Distrubution

A
  • face
  • chest
  • back/shoulders
  • ocassionaly legs, scalp
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5
Q

Mild -moderate treatment

A
  • topical retinoid
    • useful for comedonal part
    • isotertinoin
    • slows turnover of keratinocytes
    • cannot fall pregnant
  • topical antibacterial
    • ertyhromycin, clindamycin
    • try use topical preparation first - resistance
    • use with benxoyl peroxide reduce bacterisa resistance = duac
  • topical perparation
    • benzoyl peroxidase - first line
    • azaelic cid
    • side effects - bleaching irritates, photosensitizer
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6
Q

Moderate treatment

A

Oral Abx

  • reduce inflammation and P acne coonisation
  • tetracuclin most common and safetly used

Dianette

  • anti-androgen contraceptive i.e dianette
  • hormonal treatment - reduced sebum production
  • possible DVT risk
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7
Q

Severe treatment

A

Oral retinoid

  • reduce sebum production, inflam
  • concentrated with vitamin A
  • pharmacology
    • lmg/kg - 16 weeks
    • only subscribed by dermatologist
  • side effects- derrangedd LFTs, teratogenic, do not give to rpegnant women
  • pregnancy prevention programme
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