Acid-Base Reactions MasterOrganicChemistry.com Flashcards
MasterOrganicChemistry.com
What are the 4 major classes of reactions in Organic Chemistry?
Draw the reactions
At least 80% of org1 reactions are one of these four
The Four Components Of Every Acid Base Reaction In Organic Chemistry
Draw the reaction
Name them
What is Na
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Rank from least stable to most stable
the negative charge of the following ions
NH2
F
OH
CH3
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Which Of These Acid-Base Reactions Would Be The Most And Least Favorable?
Why?
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Relate stability of lone pair electrons to basicity
Relate strength of acids and bass to their conjugates
The Stronger The Acid, The Weaker The Conjugate Base (And Vice Versa)
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Acid base reactions
Draw the reactions
Identify the bonds broken
Identify the bonds formed
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Acid base reactions
A bond is …. and …. with ….
Draw the reactions
Bonds in next question
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Name the four actors in this reaction and their relation to H
Identify the bonds broken and formed
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What is the most important measure you can learn in Organic Chemistry?
Define it using HB
pKa is the negative base-10 logarithm of the acid dissociation constant (Ka) of a solution. … The lower the pKa value, the stronger the acid
Define Bronsted Acid/base and Lewis Acid/base
Define conjugate base and conjugate acid
What is pKa range of strong acid?
pKa is the negative base-10 logarithm of the acid dissociation constant (Ka) of a solution. … The lower the pKa value, the stronger the acid
Strong acids have … conjugate bases
Strong bases have … conjugate acids
Five key factors that affect acidity
Charge
The role of the atom
Resonance
Inductive effects
Orbitals
How does charge affect acidity?
How does acidity change with position in the periodic table?
Note that this trend also holds for H2O and H2S, with H2S being about 10 million times more acidic.
What effect does resonance have on a conjugate base
A huge stabilizing factor for a conjugate base is if the negative charge can be delocalized through resonance. The classic examples are with phenol (C6H5OH) which is about a million times more acidic than water, and with acetic acid (pKa of ~5).
How do electronegativity and distance affect acidity?
How does the s character of an orbital affect acidity?
