ACID BASE DISTURBANCES Flashcards
Indicator of H+ Concentration, reflects acidity or alkalinity in blood
Plasma pH
Normal plasma PH is
7.35-7.45
What are the plasma PH homeostatic mechanisms?
-Buffer System
- Kidneys
- Lungs
Prevents major changes in the pH of body fluids
Buffer System
Carbonic acid buffer system
Bicarbonate
Removes or releases H+
Buffer System
What is the ratio of bicarbonate to carbonic acid buffer system
20:1
It is regulated by the kidneys
Bicarbonate (HCO3)
It is regulated by the lungs
Carbonic Acid
Regulate the bicarbonate level in the ECF
Kidneys
Able to regenerate bicarbonate ions and/or reabsorb the ions from the renal tubular cells
Kidneys
A base bicarbonate deficit
Metabolic Acidosis
Occurs when an acid other than carbonic acid accumulates in the body or when bicarbonate is lost from body fluids.
Metabolic Acidosis
What are the causes of metabolic acidosis? (DSLR)
-Diabetes Ketoacidosis
-Severe diarrhea
-Lactic acidosis
- Renal disease
Clinical Manifestations of Metabolic Acidosis
-Kussmaul respiration (deep, rapid breathing)
- Peripheral vasodilation (warm, flushed skin)
- Hypotension
- Hyperkalemia
- Dysrhythmia
- N&V
- Headache
-Drowsiness
-Confusion
-Coma