ACETAMINOPHEN OD

Question 1

STAGE 1

Answer 1

0-24hrs
Liver Effects - preclinical
S&S
- General Malaise
- nausea / vomiting
- diffuse abdominal pain
- possibly asymptomatic
- minimal signs and symptoms
- normal liver function tests..possibly

Question 2

STAGE 2

Answer 2

24 - 72hrs
Liver Effects - Hepatotoxicity
S&S
- RUQ pain.. possibly
- clinically asymptomatic.. possibly
- AST and ALT begin to rise and.. possibly bilrubin
-coagulopathy studies (pt, ptt, inr) may increase.. if severe injury

Question 3

STAGE 3

Answer 3

72 - 96hrs
Liver effects - Hepatic failure with encephalopathy
S&S
- Liver function tests peak
- Clinical signs and symptoms of liver failure are evident including
- Jaundice
- vomiting
- gi upset
- coagulopathy
- encephalopathy
- metabolic acidosis
- pancreatitis … possibly
- acute renal failure… possibly

Question 4

STAGE 4

Answer 4

> 96hrs
Liver effects - survival or death
S&S
- full resolution of hepatotoxicity or and
- multi organ failure and death