ACEi & ARBs - Kruse

Question 1

drugs ending in ‘-artan’

Answer 1

angtiotensin receptor blockers

Question 2

drugs that block renin secretion

Answer 2

propranolol

clonidine

Question 3

renin inhibitors

Answer 3

aliskiren

Question 4

MOA: ACEi

Answer 4

inhibition of ACE and prevents formation of ang II, also prevents inactivation of bradykinin

Question 5

Tx:ACEi

Answer 5

HTN, nephropathy, heart failure, left ventricular dysfunction (alone or post MI), acute MI, cardiovascular event prophylaxis

Question 6

AE: ACEi

Answer 6

• hypotension
• acute renal failure
• hyperkalemia
• dry cough
• angioedema

Question 7

CI: ACE

Answer 7

pregnant women

Question 8

DI: ACE

Answer 8

• K supplements or K sparing diuretics ( = hyperK+)

- NSAIDs (= impaired antiHTN effects)

Question 9

conditions causing hypoperfusion

Answer 9

• hypotension
• renal artery stenosis
• dehydration
• CHF

Question 10

MOA: ARBs

Answer 10

selective blockade of ang II receptors (AT-1 type)

Question 11

Tx: ARBs

Answer 11

HTN, nephropathy, heart failure, HF or left ventricular dysfunction post MI, acute MI, cardiovascular event prophylaxis

Question 12

CI: ARBs

Answer 12

• pregnancy

- nonDM renal disease

Question 13

DI: ARBs

Answer 13

K sparing diuretics

Question 14

only ACEi’s that aren’t prodrugs

Answer 14

• captopril

- lisinopril

Question 15

MOA: colidine

Answer 15

• alpha2-receptor agonist in the brainstem

- inhibition of sympathetic vasomotor centers

Question 16

MOA: propranolol

Answer 16

• nonspecific antagonist of andrenergic beta-blockers

- work on JG cells

Question 17

MOA: Aliskiren

Answer 17

• oral renin inhibitor

- dose dependent reduction in plasma

Question 18

CI: Aliskiren

Answer 18

• pregnancy: possible fetal and neonate morbidity and mortality
• kidney insufficiency: use cautiously

Question 19

ARB metabolized by CYP450

Answer 19

losartan

Question 20

drugs ending in ‘-pril’

Answer 20

angiotensin converting enzymes