ACE inhibitors Flashcards
1
Q
Captopril
A
Capoten
2
Q
Enalapril
A
Vasotec
3
Q
Lisinopril
A
Zestril/Prinivil
t1/2 = 13 hours
4
Q
Benazepril
A
Lotensin
t1/2 = 10 hours
5
Q
Fosinopril
A
Monopril
6
Q
Moexipril
A
Univase
7
Q
Quinapril
A
Accupril
8
Q
Ramipril
A
Altace
9
Q
Trandolapril
A
Mavik
10
Q
Perindopril
A
Aceon
11
Q
MOA of ACE inhibitors
A
- decreased formation of angiotensin-2
- increased levels of circulating bradykinin
- increased formation of angiotensin 1-7 (indirect)
- Chronic Use: increase in renin levels and activity due to negative feedback of Angiotensin-2 depression
12
Q
Location of AT1 receptor: Vasculature
What is the effect?
A
- Vasoconstriction
2. Smooth Muscle hypertrophy
13
Q
Location of AT1 receptor: Adrenal Cortex
What is the effect?
A
Synthesis and secretion of aldosterone –> increases Na/H2O retention
14
Q
Location of AT1 receptor: Adrenal Medulla
What is the effect?
A
release of epinephrine
15
Q
Location of AT1 receptor: Kidney
What is the effect?
A
- Major efferent arteriole vasoconstriction –> increased GFR
- Inhibition of renin release
- Increased Na+ reabsorption in proximal tubule
16
Q
Location of AT1 receptor: Heart
What is the effect?
A
Myocardial hypertrophy and collegen synthesis
17
Q
Location of AT1 receptor: Brain
What is the effect?
A
- Release of vasopression (ADH)
- Stimulation of thirst and salt appetite
- Increased central sympathetic outflow
18
Q
Clinical Pearls
A
- Decrease/Stabilize albuminuria
- Chronic renal insufficiency is NOT a contraindication as long as you start low and go slow
- Monitor renal function (SrCr, K+)
- Limit salt intake
