Ace Inhibitors

Question 1

What does Ace inhibitors stand for

Answer 1

Angiotensin Converting Enzyme ( ACE) inhibitors

Question 2

Examples of ACE inhibitors

Answer 2

Ramipril
Lisonopril
Perindopril

Question 3

What are ACE inhibitors used for

Answer 3

Hypertension
Chronic Heart Failure
Ischemic Heart Disease
Diabetic nephropathy and Chronic Kidney disease ( CKD)

Question 4

What are the side effects of Ace Inhibitors

Answer 4

Hypotension
Dry cough
Hyperkaleamia
Renal failure
Angioedema
Anaphylactoid reaction

Question 5

What is the mechanism of action of ACE inhibitors

Answer 5

ACE inhibitors blocks the action of ACE, which is to prevent the conversion of Angiontensin 1 to Angiotenson 11.

Angiotensin II is a vasoconstrictor ( narrows the blood vessels) and stimulates Aldosterone secretion. Blocking its action reduces afterload which lowers BP.

Question 6

What are the contraindications of ACE inhibitors

Answer 6

Not to be used in patients with
Renal stenosis
Acute Kidney injury
Pregnant/ breastfeeding women

It can be helpful with some forms of CKD, only use lower doses