ACE-I Flashcards
Amiodarone, ACE-I
1
Q
Discuss the general concepts with ACE-I overdose.
A
Mild hypotension responsive to fluid therapy alone. It will manifest within 2 hours of ingestion and usually lasts several hours.
2
Q
How do ACE-I act?
A
Bind to and inactivate ACE in a reversible manner. Prevents AT-1 to AT-2 conversion. AT-2 is normally a power vasopressor + endocrine effects + reduced aldosterone. A reduction in aldosterone leads to hyperkalaemia.
