ACE-I Flashcards

1
Q

Mode of Action

A

Angiotensinogen –> Ang I –> Ang II
ACE
Bradykinin –> Inactive peptide

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2
Q

Roles of Ang II and Bradykinin

A

Ang II: Potent vasoconstrictor, inducer of Na+ and H2O retention

Bradykinin: Potent vasodilator

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3
Q

ACE enzyme characteristics

A

Zn protease
Mechanism similar to carboxypeptidase
Hydrolyses C-terminal dipeptide

3D structure orginally unknown

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