ACE-I Flashcards
1
Q
Mode of Action
A
Angiotensinogen –> Ang I –> Ang II
ACE
Bradykinin –> Inactive peptide
2
Q
Roles of Ang II and Bradykinin
A
Ang II: Potent vasoconstrictor, inducer of Na+ and H2O retention
Bradykinin: Potent vasodilator
3
Q
ACE enzyme characteristics
A
Zn protease
Mechanism similar to carboxypeptidase
Hydrolyses C-terminal dipeptide
3D structure orginally unknown