Abx Questions From Lecture

Question 1

List the cephalosporins that cover P. Aeruginosa

Answer 1

Ceftazidime
Cefeime
Ceftolozane/tazobactam
Ceftazidime/avibactam

Question 2

What is aztreonam’s spectrum of activity?

Answer 2

Gram negatives only, good for PCN-allergy

Question 3

Which FQ’s are good for gram positive, which are good for gram negative?

Answer 3

Gram positive FQ’s: Moxi and Levo

Gram negative: cipro

Question 4

What major holes does ertapenem have?

Answer 4

P. Aeruginosa
Acinetobacter
Enterococcus

Question 5

What major organisms do cephalosporins not cover

Answer 5

Listeria
Enterococcus
MRSA (except ceftaroline)

Question 6

Can daptomycin be used for PNA

Answer 6

No, it is inactivated by surfactant

Question 7

What drugs provide coverge for acinteobacter

Answer 7

Impenem vs meropenem, amp/sulbactam (unsasyn), amikacin, colistin

Question 8

What antibiotics are bactericidal

Answer 8

Beta lactams
FQs
Daptomycin
Vancomycin
Aminoglycosides
Rifampin
Metronidazole

Question 9

If a patient has Red man’s syndrome do you have to stop vancomycin

Answer 9

No, you need to slow down the infusion rate and give anti-histamine prior to infusion

Question 10

What are the toxicities of aminoglycosides

Answer 10

Ototoxicity

Nephrotoxicity

Question 11

What antibiotics are okay and not okay in pregnancy

Answer 11

Okay: penicilin, cephalosporin, flagyl (except for first trimester), bactrim (except last trimester due to risk of kernicterus), erythomycin and azithromycin, clindamycin, nitrofurantoin

NOT okay: FQ, tetracycline, chloramphenicol, bactrim in last trimester, flagyl in first trimester, sulfa near delivery