ABO Flashcards
ABO forward reverse grouping test must be done on
donors and patients
what is considered to be the major blood group
ABO blood group
what is the most frequently performed test in the blood bank
ABO bloo group system
Naturally occuring bodies
ABO blood group system
what is described by bernstein
inheritance of the ABO blood group
when was inheritance discovered by bernstein
1924
the inheritance of what genes follows mendelian genetics
ABO genes
what terminology if you inherit both A and B genes, threfore you will have AB antigens
CODOMINANT
WHAT gene IS CONSIDERED AN AMORPH
O genes
no detectable antigen is produced in response to the inheritance of these genes
amorph
what blood type are phenotype
blood type A, blood type B, blood type O
what are the genotypes
AA,AO,BO,OO
First to discover the human blood group system
Karl Landsteiner
Individual who first performed the forward and reverse grouping
Karl Landsteiner
LANDSTEINERS LAW
- The antigen on the RBC determines the blood group
- The corresponding antibody is never found in the individuals serum
- the opposite antibody is always present in the individuals serum
what antibody is naturaly occuring
ABO Antibodies
PREDOMINANTLY IgM
ABO antibodies
what is the exception in the ABO antibodies which is IgG in nature
anti-AB
why should we not perform reverse groupin on babies
production of ABO is not yet high
Detectable titers in ABO atibodies
3 to 6 months
what is the peak of ABO antibodies
5-10 years
what causes rapid intravascular hemolysis
ABO antibody
what antibody is produced by blood group A, B, AB,O
ANTI-B, ANTI-A, NONE, ANTI A, ANTI B, ANTI AB
CAN WE PERFORM FORWARD TYPING ON BABIES
YES
ABO ANTIGEN IS ALREADY AVAILABLE IN FETUS ON WHAT DAY
37TH DAY OF FETAL LIFE
WHAT ANTIGENS IS DEVELOPED FROM PRECURSOR H SUBSTANCE
A ANTIGEN
B ANTIGEN
SPECIMEN FOR BLOOD TYPING
SALIVA, PANCREATIC SECRETION, GASTRIC SECRETION
WHAT IS THE MOST COMMON BLOOD TYPE
O AND A
RAREST BLOOD TYPE
AB (ROYAL BLOOD)
WHAT ARE THE ANTIGEN PRESENT IN BLOOD TYPE A,B,AB,O
A and H
B and H
AB and H
O and H
Result from the interaction of genes of three separate loci
ABO, H, Se
precursor structure on which A and B are made
H antigen
what gene are closely linked and are located on chromosome 19
H and Se gene
ABH antigen precursor in type 2 substance
RBC
ABH antigen in type 1 precursor substance
secretions
what is the enzyme in the formation of H ANTIGEN
alpha-2-L fucosyltransferase
what is the sugar present in the formation of A antigen
N-acetyl d-galactosamine
what is the sugar present in the formation of the B antigen
d-galactose
what is the product of alleles at ABO and Hh loci
Secretor gene
how many percent of the population is secretors
80 percent
sese or SESE are the individuals that are non secretors
sese
wht are the fluids in which A,B, AND H substance can be detected in secretors
- saliva
2.tears
3.urine
4.digestive juices
5.bile
6.milk - amniotic fluid
- pathological fluid
seed extract that agglutinate human cells with some degree of specificity
lectin
genotype of blood group O
OO
Anti H antisera
ulex europaeus
blood group A genotype
A, H
LECTIN of Blood group A
dolichos biflorus
what antigen is capable of crossing the placenta
IGg
antigen of blood group A
A,H
antibody of bloo group A
anti-B
genotype of blood group B
B,H
Bandeiraea simplicifolia is revised to
Griffonia simplicifolia
what is the genotype of blood group AB
AB
antibodies in blood group AB
none
why is H very little in the antigen of blood group AB
because there is already 2 sugars added to the original structure
greatest amount of reactiviy to the least amount
0>A2>B>A2B>A1>A1B
recessive gene in bombay phenotype
hh
also called OH phenotype
Bombay phenotype
appears as group O on forward typing
Bomby phenotype