Abnormal Fetal Growth Flashcards
Standard Routine Measurements
Biparietal diameter (BPD) Head circumference (HC) Abdomen circumference (AC) Femur length (FL)
Head Measurements
BPD HC Cephalic index (CI) Transverse Cerebellum Binocular
Criteria for BPD
CSP (Cavum septum pellucidum) & thalamus No cerebellum Hemispheres symmetrical Ultrasound beam 90 degrees to midline echo Calipers placed at widest part of skull
IUGR vs SGA
DO NOT confuse IUGR with term small for gestational age (SGA).
SGA describes fetus with weight below 10th percentile without reference to cause.
Fetal growth restriction describes subset of SGA fetuses with weight below 10th percentile as result of pathologic process from variety of maternal, fetal, placental disorders.
Symmetric IUGR
All measurements small (BPD, HC, AC, FL) genetic disorders (e.g., trisomy 18), fetal infections (e.g., rubella and cytomegalovirus), congenital malformations, and a variety of syndromes (e.g., Cornelia de Lange)
Asymmetric IUGR
Head measurements correlate with age (BPD, HC)
Other measurements small (AC, FL)
relative nutritional and oxygen deprivation
Prenatal effects of IUGR
Increased mortality Decrease in umbilical vein volume Decreased cardiac output Increased cerebral circulation Heart failure
Postnatal effects of IUGR
Increased Short and long term morbidity Learning disabilities Behavioral problems Reduced cognitive function High blood pressure Diabetes Acquired heart disease
Maternal risk factors with IUGR
Low socioeconomic status/ poor maternal nutrition
Coexisting maternal disease, infection or genetic disorder incl:
Collagen vascular disease ( i.e. systemic lupus erythematosus)
Chronic and severe renal cardiovascular or respiratory diseases
Hypertension and preeclampsia
Diabetes Antiphospholipid antibody syndrome
Inflammatory bowel disease
Lung disease
Sickle cell anemia
Maternal drug use/teratogenic exposure
Hx of child of unexplained low birth wt.
Hx of IUGR pregnancy
Hx. Preterm birth
Fetal risk factors with IUGR
Aneuploidy Congenital infections ( CMV, varicella zoster) Genetic syndromes Congenital anomalies Monochorionic twins Twin to twin transfusion Higher order multiples
Placental risk factors of IUGR
Placental abruption Placenta previa Marginal or velamentous umbilical cord insertion Placental neoplasms Circumvillate placenta Advanced placental grade Placental mosaicism
weight-based theories
Low birth weight Varies with gestational age IUGR Borderline at 25% Diagnosed at 10%
weight-based theories requirements
Gestational age Estimated fetal weight (EFW) calculation BPD, AC (Shepard) HC, AC, FL (Hadlock) Gestational age (weeks), HC, AC (multiplied by 2), FL (Sabbagha) Third trimester measurements
echogenic bowel can indicate
Pathology
Doppler fetus IUGR
redistribution of blood within the fetus and placenta
what factors affect the fetal spectral waveform
- patient position
- fetal/maternal breathing
- fetal cardiac abnormalities
- maternal ingestion of pharmacologic agents
umbilical artery
normal-low resistance above the baseline
Abnormal-high resistance with no or little end-diastolic flow, possible flow reversal
Cerebral blood flow
Normal pregnancy there is continuous forward flow in the fetal MCA
MCA is the main lateral branch of the circle of Willis
High resistance circulation results in a high Doppler reading in a normal fetus (this is opposite of the case in other fetal vessels)
With fetal growth restriction, there is a marked decrease in cerebral resistance - Results in a low Doppler ratio