ABG + Acid-Base Flashcards
ABG shows a very low O2
level but the pt appears well
and is sitting up chatting. What is the most likely cause?
VBG instead of ABG by accident
ABG shows normal O2 levels
but the pt is clearly unwell & in
respiratory distress?
Patient on oxygen but not written on ABG as it should be
What is the normal PO2?
What PO2 would be considered hypoxaemic?
Normal PO2 is 11-13
Hypoxaemia is <8kPa
What is considered normal PCO2?
What PCO2 would be considered hypercapnic?
Normal PCO2 is 4.7-6kPa
Hypercapnia >6.7kPa
What is considered normal pH?
7.35-7.45
What is considered normal HCO3?
22-28 mEq/L
What are the classifications of Acute Resp Failure (3) with the definition (cutoffs) of each
Acute Type 1: Hypoxia without hypercapnia (PaO2 <8, normal/low CO2 (hyperventilation), pH normal)
Acute type 2: Hypoxia with hypercapnia (PaO2 <8, PaCO2 >6.7, pH <7.35)
Chronic Type 2: Hypoxia with hypercapnia (PaO2 <8, PaCO2 >6.7, Ph normal)
If a patient is receiving 28% FiO2 from a Venturi mask, what would you expect the PO2 to be in a healthy individual?
General rule: PO2 should be about 10kPa less than the FiO2 (%) => PO2 should be about 18kPa
What are the top 4 causes of hypoxaemia?
Give 1 example for each
Reduced PiO2/FiO2: High altitude
Hypoventilation: CNS depression, morbid obesity
Diffusion limitation: Emphysema, ILD
V/Q mismatch: PE, pneumonia
Indicate the effect of each of the following mechanisms of hypoxaemia on the A-a gradient:
Reduced inspired O2 (PiO2/FiO2):
Hypoventilation:
Diffusion limitation:
V/Q mismatch:
Reduced inspired O2 (PiO2/FiO2): Normal
Hypoventilation: Normal
Diffusion limitation: Increased
V/Q mismatch: Increased
Indicate the effect of each of the following mechanisms of hypoxaemia on the A-a gradient:
Pulmonary Embolism:
Pneumonia:
High altitude:
CNS depression:
Morbid obesity:
Emphysema:
ILD:
Pulmonary Embolism: Increased
Pneumonia: Increased
High altitude: Normal
CNS depression: Normal
Morbid obesity: Normal
Emphysema: Increased
ILD: Increased
List the causes of type 1 and type 2 ARF (5 each)
Common: Acute COPD and ARDS (more likely type 2)
Type 1: Acute Asthma, Pulmonary fibrosis, ILD, pneumothorax, pulmonary embolism!!, Congenital HD (shunt), Bronchiectasis, !pneumonia,
Type 2: Severe asthma, pulmonary oedema, opioid/sedative overdose, Neuromuscle disorders (myasthenia gravis), CNS depression, Chest wall deformities, polyneuropathy, cervical cord injury, !obestiy hypoventilation syndrome!
A 45-year-old man with no known medical conditions
comes to the emergency department due to severe
dyspnoea and chest discomfort that began earlier in the day. The dyspnoea has been worsening throughout the day and is now present at rest. Temperature is 36.7 C, blood pressure is 110/60 mmHg, and pulse is 96/min. Respiratory
rate at time of assessment is 24 breaths/min.
What is the most likely diagnosis?
What do you expect to find on ABG?
PE
Hypoxia without hypercapnia => T1RF
Acute-onset dyspnoea and chest discomfort - acute
pulmonary embolism
* PE leads to a ventilation/perfusion (V/Q) mismatch & causes hypoxaemia
* The acute hypoxaemia triggers an increase in respiratory drive and hyperventilation
In a case of PE, what would you expect the CO2 levels to be?
If treatment of a PE was not promptly performed, what can happen?
- Increased ventilation rate -> increased expiration of
CO2 -> hypocapnia -> respiratory alkalosis
an acute V/Q mismatch (e.g. PE) frequently
results in hypocapnia, respiratory alkalosis and persistent hypoxaemia
*prolonged hyperventilation -> respiratory muscle fatigue -> hypoventilation -> hypercapnia and respiratory acidosis
Arterial blood gas drawn on room air shows an arterial partial pressure of oxygen (pO2) of 7.4 kPa and an arterial partial pressure of carbon dioxide (pCO2) of 3.4 kPa.
Is this type 1 or type 2 respiratory failure?
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