Abdominal Pain pt 2 Flashcards
s/s of viral gastroenteritis
- rapid onset of diarrhea (>3x/d or 200 g of stool/d) lasting <2 wks
- stool is watery, without blood or mucus
- N/V/Abd pain (nonbilious/nonbloody)
- fever - MC in children
- dehydration - dry mucosal membranes, reduced skin turgor; in infants - lack of tear production, sunken eyes, sunken fontanelle
- abd exam - benign; hyperactive BS may be noted; (+/-) mild diffuse tenderness
w/u for viral gastroenteritits
- POC glucose - if lethargic or unresponsive
- BMP + Mg - to assess electrolytes and renal function if significant dehydration
- Stool studies are not needed (if performed will be negative)
mgmt mild-moderate viral gastroenteritis
rehydration
-
oral fluid challenge: NPO x 15 min, followed by slow 30 ml fluids, repeat oral rest x 15 min, repeat with 30 ml of fluid intake
- goal 30-100 mL/kg over first 4 hr -
oral fluid: Pedialyte or Gatorade
- soft drinks and fruit juices with high sugar content should be avoided due to risk of osmotic diarrhea
mgmt for moderate-severe viral gastroenteritis
IV NS or LR
- Adults - 500 -1000 mL bolus
- Children - 20 mL/kg
indication for antiemetic for viral gastroenteritis
- only if pt fails oral fluid challenge but meets all other criteria to be DC
- ondansetron (Zofran) ODT - SE of worsening diarrhea when utilized in viral gastroenteritis
indication for antidiarrheal in viral gastroenteritis
if diarrhea leads to dehydration
For adults only
-
antimotility - loperamide (Imodium) and diphenoxylate with atropine (Lomotil)
- avoid in pediatrics, IBD -
antisecretory - bismuth subsalicylate (Pepto-Bismol, Kaopectate)
- avoid in pediatric (Reye Syndrome) and pregnancy (salicylate toxicity)
general mgmt for viral gastroenteritis
- rehydration
- +/- antiemetic and antidiarrheal
- probiotics
- BRAT diet, avoiding lactose, raw fruit, caffeine, and sorbitol-containing products - avoid dairy x 1 wk
admission criteria for viral gastroenteritis
- a toxic appearance
- severe dehydration - abnormal electrolytes/renal function
- persistent vomiting or diarrhea
- comorbid medical conditions - pregnancy, DM, immunocompromised
- very young or elderly
- sx lasting > 1wk
viral gastroenteritis - Discharge home if the following criteria is met
- VS stable
- Normal abdominal exam
- Successful oral fluid challenge
2 processes of bacterial gastroenteritis
- toxin-mediated (secretory) diarrhea
- invasive (inflammatory) diarrhea
- large amount of watery diarrhea or bloody mucopurulent diarrhea (dysentery)
- abd cramping/tenderness
- +/- fever
dx?
complication?
- Bacterial gastroenteritis
- hemolytic uremic syndrome (HUS)
what is hemolytic uremic syndrome (HUS)
- MC elderly and children < 10 y/o
- Assoc w/ enterohemorrhagic E. Coli (EHEC)
- Hx of exposure to undercooked beef, contaminated drinking water, unpasteurized dairy or fecal contamination of raw fruits and vegetables - hemolytic anemia, renal failure, and thrombocytopenia
w/u for bacterial gastroenteritis
- (+) FOB
- BMP - hypokalemia, acute renal injury
- CBC - only if HUS is suspected
- +/- Stool studies
- Plain film / CT abdomen
indications to order stool studies for bacterial gastroenteritis
- severely dehydrated or toxic patients
- (+) dysentery
- immunocompromised patients or prolonged diarrhea (>3 days)
what pathogens must be specified for stool studies
Salmonella, Shigella, and Campylobacter MC worldwide
3 labs of stool studies
fecal leukocytes, fecal lactoferrin², stool cultures
mgmt for bacterial gastroenteritis
- Fluids
- Replace glucose or K+ if indicated
-
Abx - adults only
- ciprofloxacin, azithromycin
- Not recommended in children until a bacterial pathogen is identified -
Antidiarrheal
- avoid antimotility agents (Imodium and Lomotil) - precipitate HUS in patients with underlying EHEC infections
- Bismuth subsalicylate may be used if needed- CI in children
defining location that separates UGI bleed from LGI bleed
ligament of treitz
s/s of GI bleed
- hematemesis
- melena
- hematochezia
- Associated s/s indicating hypovolemia/shock
hematemesis is indicative of ?
- bleeding proximal to the ligament of Treitz (UGI)
- frank blood indicates moderate to severe bleeding
- coffee-ground-like emesis - mild (limited) bleeding
melena is indicative of?
- black, tarry stools - results from hgb being altered by digestive enzymes and intestinal bacteria
- UGI bleed or a right sided colonic bleed
hematochezia is indicative of?
- maroon or bright red blood or blood clots per rectum
-
can be seen with massive UGI bleeding
- factors that suggest UGI source are signs of anemia and hx of UGI bleed - MC LGI bleeding
pertinent hx for GI bleed
- Type of bleeding: hematemesis, hematochezia, melena
- Associated sx: pain; dizziness, syncope, confusion, diaphoresis, palpitations
- Pertinent hx: trauma; FBs; recent aortic or GI surgery, colonoscopy or EGD
- H/o similar sx
- 60% with a h/o an UGI are bleeding from the same lesion - Meds: NSAIDs, anticoagulants, and antiplatelet agents
- Social: alc - risk of alcoholic gastritis, chronic liver disease
what medications can simulate melena?
what food can simulate hematochezia?
- Iron or bismuth
- beets
hyperactive BS is indicative of what type of GI bleed?
UGI bleed
the presence of blood stimulates peristalsis
tenderness of abdomen with GI bleed is indicative of ?
inflammatory/infectious etiology or perforation
non-tender GI bleed is indicative of
a vascular etiology
ascites or hepatosplenomegaly with GI bleed, consider what condition?
consider coagulopathy due to liver disease
if LGI bleed is suspected, do what type of exam?
rectal
- assess for laceration, trauma, fissure, external hemorrhoids, masses
- Guaiac testing will confirm bleeding
if rectal exam is negative for blood and LGI bleed is suspected, do what exam next? (female)
Vaginal/urinary inspection
w/u for GI bleed
- Type and crossmatch
- CBC - monitored every 2-8 hours to assess severity of bleed
- CMP
- PT/INR
- EKG’s and cardiac enzymes - if MI risk
- NG tube - if suspected UGI
- will not show bleeding distal to pylorus
CBC findings for GI bleed
- normocytic RBC = acute bleed
- microcytic RBC = chronic bleed
- initial hgb - will not reflect blood loss
- >24 hours - decreased hgb due to amount of volume resuscitation
an elevated BUN:Cr ≥30 indicates what type of GI bleed?
acute UGI bleed
GI bleed - endoscopy can not be performed until INR is?
< 2.5
NG tube GI bleed - if lavage is (+) for clots or bright red blood perform ?
gentle gastric lavage with room temperature water
mgmt for Hemodynamically stable GI bleed
consult GI/Surgery for admission and scheduled endoscopy
mgmt for Hemodynamically unstable GI bleed
- NPO
- Supplemental oxygen via NC
- Cardiac monitoring
- 2 large bore IV sites
- Fluids - IV NS/LR up to 2 L bolus
- +/- Blood transfusion - 1 U FFP for every 4 U PRBC - no coag factors in PRBC
indications for Blood transfusion in GI bleed
- failure of perfusion and VS to respond to 2 L of NS/LR
- hgb < 7 grams/dL
- older pts and those with comorbidities who are unable to tolerate anemia transfuse at a hgb < 9 grams/dL
mgmt for GI bleed complicated by anticoagulation
INR > 2.0
- Hold anticoagulant/antiplatelet
- Reverse anticoagulation
- consult anticoagulant prescribing provider
- transfuse with FFP +/- reversal agent - Reverse of Factor Xa inhibitor
- andexanet alfa (Andexxa) - for rivaroxaban (Xarelto) or apixaban(Eliquis)
- idarucizumab (Praxbind) - for dabigatran (Pradaxa) - Reverse anticoagulation of warfarin
- Vitamin K
- Prothrombin complex concentrate infusions (Kcentra) if reversal agent for anticoagulant isn’t available; replaces Vit K dependent coagulation factors (Factors II, VII, IX, X) + Proteins C and S
additional mgmt for UGI bleed
- PPI - pantoprazole - bleeding from PUD
- Somatostatin analog - Octreotide - variceal bleeding, can be used as an adjunct in non-variceal bleeds
- Emergent consult to gastroenterology or general surgery for urgent endoscopy