abdominal Flashcards
GORD:
- how common?
- risk factors? 5
- triggers? 6
- causes? 3
10-20% in the west
- caucasian
- obese
- pregnant
- smoking
- some drugs (eg Ca channel blockers)
- alcohol
- coffee
- fizzy drinks
- chocolate
- fatty foods
- spicy foods
- hiatus hernia
- loss of sphincter tone
- abdominal pressure
GORD:
- symptoms? 6
- extra-oesophageal symptoms? 3
- heart burn (dyspepsia) esp after meals, relieved by antacids
- belching/burping
- food/acid regurg
- increased salivation (water brash)
- painful swallowing odynophagia
- fullness feeling
- nocturnal asthma
- chronic cough
- laryngitis/sinusitis
nb heartburn as a symptom has a very high positive predictive value
GORD:
- investigations? 3
- non-pharm treatments? 7
- try giving pharm treatments and see if symptoms subside
- endoscopy (if symptoms >4wks on treatment or cancer red flags)
- if endoscopy negative, 24hr oesophageal ph monitoring
- reduce triggers
- loose weight
- stop smoking
- take off drugs that relax muscles (Ca channel blockers, nitrites, anti-cholinergics)
- take off drugs that irritate stomach (NSAIDs, bisphosphonates)
- raise head off bed (not extra pillows)
- small meals, don’t eat 3 hours before bed
nb only do barium swallow if suspect hiatus hernia
GORD:
- pharm treatments? 3
- surgical treatments? 1
- antacids
- alginates (gaviscon)
- PPIs (better than H2-blockers)
nb antacids and alginates only relieve symptoms, don’t stop progression
- surgery to increase resting tone of sphincter (eg nissan fundoplication)
GORD:
- complications? 6
- oesophagitis
- ulcers
- oesophageal strictures
- iron deficiency
- barrets oesophagus
- pulm fibrosis (very rare)
GORD:
- differentials? 5
- oesophagitis from corrosives/candida/etc
- hiatus hernia
- gastritis (eg nsaids, h pylori)
- gastric or duodenal ulcer
- cardiac (or pulm) disease
peptic ulcers
- two types? (which most common)
- how common?
- most common causes? 2
- other risk factors? 3
- duodenal (90%) and gastric (10%)
- 10% lifetime risk
- H pylori (85%)
- drug-induced (NSAIDs, SSRIs, steroids)
- smoking
- increased age
- poor gastric emptying/increased acid secretion
describe the pathophysiology for two commonest causes of peptic ulcer disease
H PYLORI
- causes inflammation of mucosal lining
- depleting the layer of alkaline mucus + altering gastric acidity
- h pylori impairs the function of cells which produce somatostatin (norm limits acid secretion of parietal cells)
NSAIDS
- inhibit prostaglandin synthesis
- reducing the production of protective alkaline mucus
- thereby increasing risk of ulceration (particularly in stomach)
peptic ulcer disease
- symptoms? 3
- signs? 1
- difference in symptoms between duodenal and gastric ulcer?
- upper abdo pain (burning sensation, heaviness or ache)
- (bloating)
- (burping)
- tender epigastrum
duodenal ulcer = pain before meals or at night (relieved by eating!) (50% asymptomatic)
gastric ulcer = pain after/during meals (also more likely to be asymptomatic)
peptic ulcer disease:
- investigations? 2
- non-pharm treatments? 5
- C13 breath test (most accurate, non-invasive h pylori test)
- if over 55 or ALARMS signs: endoscopy
nb there are other, less used, tests
- stop NSAIDs
- reduce stress
- reduce alcohol consumption
- stop smoking
- eat less trigger food
peptic ulcer disease:
- pharm treatments? 2
if h.pylori:
- triple therapy (2 Abx + PPI)
if drug-induced:
- stop drugs
- PPI (or H2-antagonist)
nb two Abx are norm clarithromycin plus amoxicillin or metronidazole
red flags for peptic ulcer disease? 7 (6 are in an acronym)
- over 55years
ALARMS
- A = anaemia
- L = loss of weight
- A = anorexia
- R = recent onset/progressive symptoms
- M = melaena/haematemesis
- S = swallowing difficulty
peptic ulcer disease:
- differentials? 7
- functional (non-ulcer) dyspepsia
- gastritis or duodenitis
- GORD/oesophagitis
- hiatus hernia
- gastric malignancy
- pancreatic cancer
- gallstones
(- duodenal crohns)
(- TB)
(- lymphoma)
also think of possible resp or cardiac conditions
peptic ulcer disease:
- complications? 3
- bleeding
- perforation
- gastric cancer
Acute upper GI bleed:
- causes? 4
- risk factors? 4
- peptic ulcer (50%)
- oesophageal varices
- mallory-weiss tears
- gastric cancer
nb peptic erosions (ie before an ulcer) can also cause bleeding but rarely
- liver disease/alcoholism
- h pylori
- NSAIDs
- repeated vommitting (mallory weiss)
nb anti-coagulants don’t (on their own) cause bleeding but they will exacerbate any bleeding that does occur
nb there are other very rare causes!
acute upper GI bleed
- symptoms?
- signs?
- haematemesis
- melaena
- cold (+ clammy) peripheries
- decreased GCS
- poor urine output
- tachycardic
- low BP (faint pulse)
- rapid breathing
ie signs of shock
acute upper GI bleed:
- investigations? 4
- bloods (FBC, LFTs, U+E, clotting screen, group + save)
- risk scoring
- urinary catheter to monitor output
- endoscopy asap
nb give IV fluids while this is all going on
what is the name of the risk score used for upper GI bleeds
Rockall risk scoring
acute upper GI bleed:
- treatment? 5
- give IV fluids (give RBCs if v poorly)
- stop NSAIDs
- stop/reverse warfarin (or other anti-coags)
- give PPIs
(- Abx) - endoscopy or surgery depending on cause/severity
nb preferably stop drugs before endoscopy
crohn’s disease:
- risk factors? 5
- age + gender affected?
- smoking
- family history/genetics
- appendectomy
- NSAIDs
- oral contraceptives
- onset is norm between 20-40years
- men = women
nb stress + depression may precipitate relapses
crohn’s disease:
- GI symptoms? 5
- diarrhoea
- pain on defecation
- abdo pain
- malaise
- weight loss
- anorexia
nb symptoms depend on which part of GI tract affected
nb ileocaecal is most common site - 40% of patients
crohn’s disease:
- GI signs? 4
- mouth ulcers
- anal or peri-anal skin tag/fistula/abscess
- abdominal tenderness
- palpable mass in RLQ
crohn’s disease:
- extra-GI symptoms/signs? 5
- iritis
- arthritis
- erythema nodosum
- pyoderma gangrenosum
- clubbing
crohn’s disease:
- blood tests? 5
- other investiugations? 3
- FBC (for anaemia)
- U+E
- LFTs
- CRP
- ESR
- stool microscopy + culture (rule out infective causes)
- faecal calcprotectin
- endoscopy w biopsy is gold standard
nb on endoscopy see cobblestone appearance with skip lesions + transmural inflammation