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Cardio Therapeutics > AADs > Flashcards

AADs Flashcards

1
Q

Class 1A: AAD

A

-Quinidine
-Procainamide
-Disopyramide

(DQP)

*All primarily Na blockers, some K blocking

*FOR supra ventricular and ventricular

= DQP VNS

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2
Q

Quinidine

A

AE:
-Cinchonism (ND, dizzy, HA, tinnitus, visual, diarrhea)
-Hemolytic anemia
-QTP, TDP
-Thrombocytopenia

DDI:
-Warfarin
-Digoxin
-Pheno, pheny, rifampin
-Class 3 AAD
-Propafenone, flecainide
-BB, verapamil

*can produce beta receptor blockade and vaginal inhibition

=Quin is a QT goes to the PDW

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3
Q

Procainamide

A

IV
-15-18 mg/kg (max 25) LD, 1-4 mg/min MD

AE:
-Hypotension
-Lupus, BMS
-QTP, TDP
-GI, nausea, fever

DDI:
-Cimetidine, ranitidine
-Trimethoprim
-Class 3 AADs
-Diuretics

*NEGATIVE INOTROPE
*Monitor PA and NAPA (4-8, 4-10)

= she plays PRO at = QT BG NHL DIRTC

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4
Q

Disopyramide

A

Dose range: 300-1200
-decrease if CHF, HI, RI
-d/c if qrs/qtc increases by 25% or if heart block occurs

AE:
-Anticholinergic
-Hypotension
-Heart failure
-Proarrhythmia = TDP

DDI:
-Pheny, pheno, rif
-Class Ia, Ic, III
-Erythromycin
-Diuretics
-Digoxin
-Tricyclic AD

PAHH PGP TEDD

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5
Q

Class 1B: AAD

A

-Lidocaine
-Mexiletine

Primarily Na blocker

FOR VENTRICULAR arrhythmias

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6
Q

Lidocaine

A

LD 1-1.5 mg/kg
MD 1-4 mg/min

AE:
-CNS
= 5+: confusion, dizzy, vertigo, numb, tinnitus
= 9+: psychosis, seizure, sinus arrest, heart block

DDI:
-Cimetidine
-Pheny, pheno, rif
-BB

B CPR

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7
Q

Mexiletine

A

600-1200 mg/day

AE:
-CNS (tremor)
-Proarrhythmias
-GI upset
-Thrombocytopenia

DDI:
-Cimetidine
-PPR

PACC G to mex

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8
Q

Class 1C: ADD

A

-Flecainide
-Propafenone

Primarily Na blocker
-QRS/QT/PR widens

FOR supra ventricular and ventricular
(rarely for ventricular tho)

BOTH CI IN STRUCTURAL HEART DISEASE

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9
Q

Flecainide

A

200-400 mg/day

AE:
-Proarrhythmia
-CHF new/worsening
-Heart block
-CNS: bv, diz
-GI upset: NV

DDI:
-Amiodarone
-Cimetidine
-Digoxin
-BB, CCB (VD)

CI: structural HD

FLEX CCC DABAGS

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10
Q

Propafenone

A

300-900 mg/day

FOR maintain SR in SVT Arr (AF)

AE:
-Proarrhythmia
-CHF worsens
-Bronchospasm
-CNS
-GI, metallic taste

DDI:
-Digoxin
-Warfarin
-Cimetidine
-Cyclo, theo, BB
-PPR

CI: structural HD and asthma/COPD

none CAB to GMC

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11
Q

Class 2: AAD

A

Beta blockers
-Atenolol, metoprolol, esmolol

FOR terminating re-entrant and ventricular rate control in AF

AE:
-Brady, hypo, AV block
-CHF worsening
-CNS, GI
-Bronchospasm, dsyp
-Hypo/hyperglycemia, lipid

DDI:
-Cimetidine
-Verapamil

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12
Q

Esmolol Specific Indication

A

Also used to control wall stress in acute aortic dissection

LD 500 mcg/kg
MD 50 mcg/kg/min

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13
Q

C3: Amiodarone

A

-FOR VT, VF, AF, AF1, sinus rhythm maintaining

AE:
-TDP
-Pulmonary fibrosis
-Thyroid
-Per neuropathy
-High LFTs
-Corneal microdeposits
-Macular degen
-Skin discoloration
-Phlebitis
-Hepatitis

DDI:
-Thiazide, mycin, zole TCAD
-Phenytoin
-Warfarin
-Digoxin

Caution: Iodine allergy

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14
Q

Dofetilide

A

Class 3
-FOR AF/1 conversion to sinus rhythm and maintaining

CRCL DOSING
-20-60, dose is 125-500

AE:
-HA, dizzy, nausea, flu
-Tachycardia, TDP, VF, QTP, AV block

DDI:
-Verapamil
-Cimetidine
-Megestrol
-Trime, azole, prochloro

Avoid in QTc 440+

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15
Q

Ibutilide

A

Class 3
-FOR AF/1 conversion to SR

AE:
-Every arrhythmia
-AV block
-HA, NV, hypotension

Avoid in QTc 440+

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16
Q

Dronedarone

A

Class 3
-FOR AF/1, maintain SR, reduce ventricular rate

AE:
-NVD, rash, QTc, liver injury, asthenia

Less ae than amiodarone but less effective

DONT use in permanent AF/1

DONT use in Brady (HR < 50), QTc 500+, or 2/3 heart block

CI (QB has AB)

17
Q

Sotalol

A

Class 3
-FOR AF/1, VT

AE:
-Fatigue, dep, Brady, NVD, QTP, TDP, broncospasm

DDI:
-Diuretics
-Verapamil, diltiazem
-Amiodarone
-Phenothiazines

18
Q

Class 4: AAD

A

-Diltiazem
-Verapamil

FOR automatic or reentrant tachy from SA/AV nodes
and
terminating arrthymias and controlling VR in AF

19
Q

Class 4: AE

A

-Brady, AVB, hypotension, dizzy, HA, lethargy, GI

Dilt; edema

Vera; proarrhythmias

20
Q

Class 4: DDI

A

Diltiazem
-Propranolol, nitrates, statins (SAL)

Verapamil
-Statins, digoxin, PPR

21
Q

Adenosine

A

Max 30 mg, 20-30 ml saline flush must be given right after

AE: HA, dysp, flushing, asystole, broncho

DDI: Theo, caffeine, dipyridamide

1st line for:
-Terminating PSVT
-AV nodal reentry
-Concealed accessory pathway

CATA

22
Q

Digoxin

A

AE: GI, neuro, cardiac, blood
-arrhythmias, cog, vision

DDI: PGP, verapamil, quinidine, amiodarone, propa, flecainide

Reserved for VR control in AF pts with low EF or HF or when other agents maxed

Cardio Therapeutics (31 decks)

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