AAAST 2 Flashcards
Superinfection means
Destruction of normal flora
Hirap sa gram neg organisms
Beta lactam drug
Increase permeability, acts like detergent
Polymyxins
Action against gram posi and nega bacte
Broad spectrum
Methicillin and oxacillin are what kinds of penicillin
Penicillinase Resistant Penicillins
Another name for peptidoglycan layer
Murein layer
Cephalosporin is what kind of drug
Beta lactam drug
MOA: binds to terminal D ala D ala
Glycopeptides
PBP means
Penicillin binding Protein
Drug for anaerobes, microaerophiles, protozoans
Metronidazole
Limited to gram positive organisms because it is a large molecule
Glycopeptide
Penicillin G pano pinapasok
Intramuscular
Recycle certain metabolites
Bacitracin
Cycloserine MOA
inhibit synthesis of peptidoglycan precursors in cytoplasm
Prevent dihydrofolate reductase
Trimethoprim
Bind and interfere with DNA gyrase and Topoisomerase IV
Fluoroquinolones
PABA means
Para amino benzoic acid
Last resort to Pseudomonas aeruginosa and Acinetobacter (?) infections
Polymyxins
First line drugs antimycobacterial agents (3)
Isoniazid, rifampicin, pyrazinamide
Generation of cytotoxic compounds and free radicals that disrupt DNA
metronidazole
Block formation of 7,8 dihydropteroate
Sulfonamides
Important precursor in dna synthesis of bacteria
Folate
Inhibit translation through inhibition of elongation step by binding to 23s RNA..
Macrolides
Inhibit mycolic acid
Antimycobacterial agents
Cyclic polypeptides
Polymyxins
Oral medication penicillin type
Penicillin V
MOA Formation of covalent complexes with enzymes that generate peptidoglycan molecule
Beta lactam drugs
NAG and NAM is in
Peptidoglycan layer
Clostridium dificile is related to what infection
Superinfection