AAAST 1 Flashcards
Used together with penicillins often
Aminoglycosides
Calcium chelated
Tetracycline
Antimicrobial susceptibility has been lost
Clinical resistance
Short dna sequences - transposable element
Insertion sequences
Inhibit protein synthesis (2)
Tetracycline and dexocycline
Reduced susceptibility of an organism to a microbial agent
Biological resistance
Formation of persister cells
Biofilms
Inherent resistance of Gr (-) bacteria to Vancomycin
Impermeability; intrinsic resistance
INTRINSIC OR ACQUIRED RESISTANCE
Decreased penetration of antibiotic
Intrinsic
Production of enzymes that destroy antimicrobial agents
Enzyme inactivation
INTRINSIC OR ACQUIRED RESISTANCE
Embedded in exopolysaccharide matrix
Intrinsic
Acquired resistance happen due to
Abuse of antibiotic
MRSA means
Methicillin Resistant Staphylococcus aureus
INTRINSIC OR ACQUIRED RESISTANCE
Resistance to beta lactam drugs
Acquired
ESBL
Extended Spectrum Beta Lactamase
What r the ESBLs
Enterics
Drug of choice for MRSA
Vancomycin
Jumping genes
Transposons (?)
INTRINSIC OR ACQUIRED RESISTANCE
Glycopeptide resistance
Acquired
For mycoplasma, treponemes, rickettsia
Macrolides
INTRINSIC OR ACQUIRED RESISTANCE
Biofilms
Intrinsic
Enzymatic alterations involving a plasmid borne variant of an enzyme
Resistance to quinolones
Inhibit protein synthesis by interacting with 23s rRNA
Linezolid
Most important strategy of bacteria to spread resistance
Lateral gene transfer
Resistance to folate pathway inhibitors mean
Target site substitution
Causes pseudomembranous colitis
Clindamycin
Linezolid is a
Oxazolidinones
Used before for typhoid
Chloramphenicol
Limited spectrum of action
Narrow spectrum
Mobile genetic elements
Integrins
Meaning of resistance to macrolides
Altered cell wall precursors unable to bind to vancomycin