AA in synthesis of specialized products- Brar Flashcards
What 2 things are needed to make heme?
Glycine and Succinyl CoA
What inhibits heme synthesis?
Iron and Heme (1st rxn)
Lead (rxn 2 and final rxn)
What type of porphyrins are physiologically important for humans?
Type III
What is the AA precursor to catecholamine biosynthesis (Dopamine, NorEpi and Epi)? Basic rxn? Necessary cofactors?
Phenylalanine–>Tyrosine–>Dopa (rate limiting step)–>dopamine–>NorEpi–>Epi
Whole rxn requires: tetrahydrobiopterin, ascorbate (vitamin C), SAM
What is the AA precursor to Serotonin biosynthesis? Basic rxn? Necessary cofactors?
Tryptophan–>5-HTP–>5-HT (serotonin)
Requires: tetrahydrobiopterin and O2
What is the AA precursor to histamine biosynthesis? Basic rxn? Necessary cofactors?
Histidine → Histamine + CO2
Requires: PLP (vitamin B6)
What is the AA precursor to melanin biosynthesis?
tyrosine
What are the AA precursors to glutathione biosynthesis? Necessary cofactors?
glutamate, cysteine and glycine
Requires: NADPH
What is the AA precursor to Nitric Oxide biosynthesis? Necessary cofactors?
L-Arginine
Requires: NADPH and O2
What is the AA precursor to GABA biosynthesis?
Glutamate
What is the major precursor to NAD/NADP biosynthesis? What is the secondary AA precursor?
Niacin (Vit. B3)
Tryptophan
What is the AA precursor to thyroid hormone biosynthesis?
Tyrosine
