A child with epilepsy / first fit Flashcards

1
Q

what headaches are seen in children? what are the features associated with each?

A
  • Usually seen in older children
  • Primary headache (primary malfunction of neurones; NICE)
  • Migraine
  • Tension type headache
  • Symmetrical, gradual onset
  • Described as a tightness, band or pressure • No other symptoms
  • Cluster headaches
  • Severe headache to one side of head
  • May be seen around the eye
  • There may be eye watering or nasal congestion
  • Cough and exertional headaches
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2
Q

List causes of secondary headaches in children

A
  • Secondary headaches:
  • Symptomatic of underlying pathology – SOL, Raised ICP
  • Head and neck trauma
  • Vascular disorders
  • Non vascular disorders
  • Medication / drug overuse
  • Infection – meningitis /encephalitis • Disorders of homeostasis
  • Hypercapnia; Hypertension • Acute sinusitis
  • Trigeminal / cranial neuralgias
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3
Q

Headache Red flag signs & symptoms in children

A
  • Symptoms
  • Acute headache with fever (consider meningitis)
  • Headache – worse on lying down
  • Headaches – wakes up child
  • Associated early morning nausea/vomiting, confusion • Change in personality or behaviour
  • Signs
  • Growth failure
  • Visual field defects/ squint/ papilloedema • Cranial nerve abnormalities
  • Torticollis
  • Ataxia
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4
Q

Management of headaches in children

A
  • Thorough history and clinical examination
  • Detailed explanation
  • Advice
  • Lifestyle changes • analgesics
  • Imaging unnecessary if no ‘red flag signs’
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5
Q

Describe the symptoms of Migraine in children

A
  • Migraine without aura (90%)
  • Unilateral or bilateral headache
  • Pulsatile over temporal or frontal area • Unpleasant GI symptoms
  • Aggravated by physical activity
  • Migraine with aura (10%)
  • Headache preceded by aura (visual, sensory or motor) • Visual –negative phenomena hemianopia or scotoma
  • Positive – fortification spectra – zig zag lines
  • Last a few hours, prefer quiet dark place • Sleep relieves the bout
  • Genetic predisposition
  • Triggering factors
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6
Q

Management of migrane in children

A

• Migraine
• Acute management
Management
• Early analgesic use, NSAID/paracetamol
• Oral triptan (nasal preparations available for >12 yr of age)
• Transcutaneous electrical/magnetic stimulation (specialist advice)
• Prophylactic treatment
• Avoidance of triggers/ lifestyle changes – hydration, sleep
• Topiramate (fetal malformations, consider contraception for girls) • Propranolol
• Amitriptyline
• Acupuncture

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7
Q

Motor disorders in children

• Corticospinal tract disorders symptoms and signs

A
  • Weakness with adduction at shoulder
  • Flexion at elbow, pronation of forearm
  • Adduction and internal rotation at hips, with flexion at hip and knee
  • Plantar flexion at ankle
  • hyper-reflexia, extensor plantars
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8
Q

Motor disorders in children

• Basal ganglia disorders symptoms and signs

A

• Fluctuating tone, dystonia, dyskinesia

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9
Q

Motor disorders in children

• Cerebellar disorders symptoms and signs

A

• posture difficulty, coordination, nystagmus, dysarthria

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10
Q

Motor disorders

• Peripheral symptoms and signs

A
  • Key feature is weakness (progressive or static) • Delayed development
  • Floppiness
  • Muscle weakness or cramps
  • Sites affected
  • Anterior horn cells – Spinal Muscular Dystrophy, Polio
  • Peripheral nerve – hereditary motor sensory neuropathies, post- infectious polyneuropathy (Guillain-Barre), Bell’s palsy
  • Neuromuscular transmission – Myasthenia Gravis
  • Muscle – muscular dystrophy (Duchenne’s), inflammatory myopathies, myotonic dystrophy
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11
Q

Neural tube defects pathophysiology

A
  • Failure of normal fusion of the neural plate to form the neural tube in fetus
  • Prevalence dramatically fallen • Improved maternal nutrition • Folic acid supplementation
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12
Q

what is the difference between Anencephaly and Encephalocele

A

Anencephaly – failure of development of most of cranium & brain. Stillborn or die shortly after birth

• Encephalocele – extrusion of brain & meninges through a midline skull defect

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13
Q

what is Spina bifida occulta

A
  • Incidental finding on Xray

* Tuft of hair, dermal sinus in lumbar region

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14
Q

what is the difference between Meningocele and Myelomeningocele. what is the Treatment ?

A

Meningocele – cystic lesion with meningeal extension covered by skin
• Good prognosis
• Myelomeningocele – open sac that contains dysplastic spinal
cord and nervous tissue
• Associated muscle, bladder, bowel problems • Scoliosis
• Treatment – MDT, Symptomatic and supportive management

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15
Q

Pathophysiology of Hydrocephalus

A

• Obstruction to the flow of CSF, leading to dilatation of ventricular system proximal to site of obstruction
• Non-communicating (obstructive – within the ventricular system)
• Congenital
• Aqueduct stenosis
• Chiari malformation (cerebellar herniation through foramen magnum)
• Communicating (arachnoid villi – site of CSF absorption) • Intracranial haemorrhage
• Meningitis
Remember the HEAD CIRCUMFERENCE in a child whose fontanelle has not closed

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16
Q

Hydrocephalus - clinical features

A
  • In infants
  • Head circumference grows disproportionately • Sutures separate
  • Anterior fontanelle bulges
  • Scalp veins distended
  • Advanced sign - ‘sun setting of the eyes’
  • Older children
  • Raised intracranial pressure
17
Q

Hydrocephalus - Investigations

A
  • Antenatal ultrasound screening
  • Routine scans in preterm babies
  • Head circumference monitoring
  • CT or MRI
18
Q

Hydrocephalus - Treatment

A
  • Symptomatic relief of raised ICP and minimise neurological damage
  • Ventriculo-peritoneal shunt • Endoscopic ventriculostomy
19
Q

Neurofibromatosis - signs

A
  • Neurofibromatosis – Autosomal dominant
  • Café-au-lait patches (size matters!) , Neurofibroma
  • Axillary freckling, Optic glioma
  • Lisch nodule (hamartoma of iris)/Bony lesions/First degree family history
20
Q

Tuberous sclerosis - signs

A

Autosomal dominant
• Ash-leaf patches
• Development delay, epilepsy
• Calcified lesions on CT scan

21
Q

Sturge – Weber syndrome - signs

A

• Haemangiomatous lesion (Port-wine stain) in trigeminal nerve distribution associated with intracranial lesion ipsilaterally

22
Q

Neurodegenerative disorders key features

A
  • Deterioration in motor and intellectual function • Development stops and then regresses
  • Abnormal neurological features
  • Seizures
  • Involuntary movements
  • abnormal head circumference • Loss of vision and hearing
23
Q

Non-epileptic events that are differential for seizures

A
  • Breath holding attacks
  • Reflex Anoxic seizure
  • Syncope
  • Staring related to inattention (day dreaming)
  • Migraine
  • Benign paroxysmal vertigo
  • Others
  • Cardiac arrhythmia
  • Pseudo-seizures
  • Fabricated illness
  • Induced illness (non accidental injury)
  • Tics, night terrors
24
Q

Febrile seizures - will they reoccur?

A

30-40% will have further episodes after first

25
Q

Key messages for parents after Simple febrile seizures

A
  • Do not cause brain damage
  • Subsequent intellectual performance remains the same
  • 1-2% risk of epilepsy - same as all children
26
Q

Key messages for parents after Simple febrile seizures

A

If focal, prolonged or repeated in same illness, increased risk of 4-12% of epilepsy (compared to 1-2% in simple febrile)

27
Q

Definition of seizure

A

Sudden disturbance of neurological function caused by abnormal or excessive neuronal discharge

28
Q

Definition of epilepsy

A

Epilepsy is a chronic neurological disorder characterised by recurrent unprovoked seizures, associated with abnormal neuronal activity in the brain

29
Q

Red flags to cover in history for seizures

A
  • Seizures lasting more than 5 minutes
  • Symptoms of raised intracranial tension
  • Signs related to intracranial infection
30
Q

You are GP to a child with first afebrile seizure. What should you do?

A

GP to refer to a paediatrician

31
Q

Children presenting to Emergency department following a seizure

A
  • Laboratory tests
  • 12 lead ECG
  • If unusual, consider neurometabolic screen

Imaging
•Not warranted in every child
•CT or MRI scans (how to decide)
•In acute situation consider CT

32
Q

True or false: Normal EEG does not rule out epilepsy

A

True

33
Q

Should child be treated after first seizure?

A

•Single seizure – do not treat

Anti epileptic drug therapy (AED)
•Not all seizures require therapy
•Description of the seizure type, epilepsy syndrome, etiology and comorbidity will direct management!
•Monotherapy at minimum dosage
•Drug levels not routinely measured
•AED discontinued after 2 years seizure free

34
Q

Advice to children with epilepsy

A
  • School to be made aware of
  • Unrecognised absences – affect learning
  • Restrictions: Avoid deep baths; PE at heights; Cycling on busy roads

Adolescence
•Driving – 1 year seizure free
•Contraception and pregnancy
•SUDEP and its low risk emphasised