A- Ageing Flashcards

1
Q

What is Ageing (biological)?

A

‘Complex biological process in which changes at the molecular, cellular and organ levels results in a progressive inevitable and inescapable decrease in the body’s ability to respond appropriately to internal and/or external stressors’

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2
Q

Characteristics of ageing

A

Increased mortality
Increased susceptibility & vulnerability to disease
e.g. >65 years, 92 times more likely to get heart disease
Changes in biochemical composition of tissues
Increased protein crosslinking, aberrant folding, lipofuscin accumulaton
Decrease in physiological capacity
e.g. reduced glomerular filtration rate, max. heart rate
Reduced ability to respond to environmental stimuli

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3
Q

Old Theories of ageing (3)

A

> Galen (AD129- 199)
Changes in body humours beginning in early life
Slow increase in dryness & coldness of the body

> Roger Bacon (1220-1292)
Wear & tear theory
Result of abuses & insults to the body
Good hygiene may slow process

> Charles Darwin (1809-1892)
Loss of irritability in nervous & muscular tissue

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4
Q

Programmed theories of ageing

A
  • Biological clocks
  • Purposeful programme driven by genes

e.g. Evolutionary

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5
Q

Non programmed (error, stochastic) theories of ageing

A
  • Progressive random, accidental damage
  • Loss of molecular fidelity

e. g. Molecular/cellular
e. g. System

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6
Q

Evolutionary theory of ageing

A

Genome directs life until sexual maturity.

No selective pressure after this.

Late onset diseases eg Huntington’s disease (30-40 years) not selected in a way that early ones are eg sickle cell anaemia

Some genes selected early in life may be deleterious later (e.g. immune system, androgens)

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7
Q

Molecular/Cellular (non-programmed):

theory of ageing

A

Free radical damage to molecules

Increased frequency of senescence

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8
Q

System (non-programmed):

theory of ageing

A

Neuroendocrine alterations result in age related physiological changes.

Immunologic function declines- decreased resistance to infection, cancer & increased recognition of self.

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9
Q

Ageing genes: Syndromes

A

> Hutchinson-Guilford Progeria

> Werner syndrome

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10
Q

What is Hutchinson-Guilford Progeria?

A

Rare genetic disorder.
Mutation in LMNA encoding nuclear envelope protein: lamin A.

Affects RNA transcription & chromatin organisation.

Lack of DNA strand rejoining after irradiation.

Accelerated ageing (atherosclerosis).
Usually die by 13.
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11
Q

What is Werner syndrome?

A

Mutation in WRN, DNA helicase family
‘caretaker of the genome’: DNA repair and transcription.

Baldness, hair and skin ageing, calicification of vessels, cancers, cataracts, arthritis, diabetes.

Die by age 50
Central control of ageing?

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12
Q

How many times do cells usually divide?

A

Approx. 50 times

Decline in proliferative capacity
Senescence
Cancer cells have no limit (immortal)

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13
Q

What happens to telomeres with age?

Telomeres= DNA sequences
Protect the ends of chromosomes

A

Progressive shortening with age

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14
Q

What are telomerases?

A

Reverse transcriptase.
Stabilizes telomere length.

Telomerase activity in 90% tumours

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15
Q

Lifestyle effect on ageing?

A
  • sedentary= genetically old

- Telomeres shorter more quickly in inactive people

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16
Q

What is Molecular ageing?

A

Conformational change, aggregation, precipitation, amyloid formation

Ageing: catabolic chance driven?

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17
Q

Free radical effect on ageing?

A

Accumulation of oxidative damage in proteins & DNA

Damage to mitochondrial DNA.

Antioxidants to counter ageing (Vit C, E, β-carotene, 2-deoxy glucose)

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18
Q

Skin ageing features-

A

Wrinkles, pigmented lesions etc.

Sun exposure, air pollution, alcohol, poor nutrition.
Smoking- increase in metalloproteinase enzymes which break down collagen.

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19
Q

Calorific restriction to decrease ageing rate-

A

Reduced oxidant production by mitochondria- less ROS damage.

Induction of SIRT1- key regulator of cell defence.

Increased protein turnover- lack of accumulation of damaged protein.

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20
Q

Healthy life expectancy definition?

A

Summary measure of population health, estimates based on question ‘How is your health in general?’

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21
Q

Disability-free life expectancy definition?

A

Estimates based on those who answer yes to both:

Do you have any physical or mental health conditions or illnesses lasting or expected to last 12 months or more?

Does your condition or illness/do any of your conditions or illnesses reduce your ability to carry out day-to-day activities?

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22
Q

What is ‘Old age’?

A

What it means to age and be a particular age in a given society varies

This means that what ‘old age’ is varies and so it is socially constructed

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23
Q

What is ageing?

A

combination of biological, psychological and social processes that affect people as they grow older

  • Physical changes to the body
  • Shifts in mental processing capacity
  • Changes in society and the social context in which people are ageing
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24
Q

Laslett (1989) proposed different dimensions to age and ageing (5)

A

Chronological (length of life measured in years since birth)

Biological (physical ageing, based on changes in health, fitness, functioning and appearance)

Social (norms and expectations relating to age)

Personal (moment in the life course reached in relation to personal aims)

Subjective (how we feel ‘inside’)

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25
( 1) What is the life course and how does this relate to ageing?
Ageing is a process that continues from birth to death, although the transitions between different phases are not pre-determined A life course approach includes both consideration of people’s social surroundings, and stories of people’s lives over time
26
What is (2) Age strata and age cohorts and how does this relate to ageing?
Age strata – people who share similar social rights and duties by virtue of age Age cohort – people born at a particular time who have experiences in common
27
Social contexts of dental treatment with ageing Cumulative effect of experiences and events over the life course
Social contexts of dental treatment: Prevalence of caries Lack of equipment and pain relief Multiple teeth removed under anaesthetic leading to lifelong fear
28
Various mechanisms that affect experiences of dentistry and oral health
- Legal rule changes - Ongoing research - Social campaigning - Changes to beliefs > changes to social rules/norms (Shaped by social, cultural and material changes)
29
What are Theories of older age? (2)
Theories as a way of explaining particular phenomena How ageing is viewed and experienced
30
Give 4 examples of theories of older age:
1. Disengagement theory 2. Structured dependency theory 3. Cultural gerontology 4. Critical gerontology
31
What is the disengagement theory?
Functionalist theory: focuses on how elements of society work together - Growing old is an inevitable mutual withdrawal or disengagement resulting in decreased interaction between an ageing person and others in the social system he belongs to... - Irreversible process
32
What is the 2) Structured dependency theory?
Individuals are not free to act in any way they see fit. - focuses on ways in which social institutions shape people’s lives. Dependency structured by retirement, poverty, institutionalisation in residential and nursing homes and the restriction of domestic and community roles.
33
What are some Barriers faced by older people in accessing oral health care?
Limitations to domiciliary care, lack of knowledge and training, poor monitoring of care Lack of equipment in care homes, limited time and reimbursement for leaving private practice
34
What is the 3. Cultural Gerontology theory?
Focus on role of culture (varied and complex systems of meaning that constitute everyday life). Multiple cultures of ageing, with different representations of old age: 1) The third age 2) The challenge of individualisation 3) The fourth age
35
What is the third age?
Life after responsibilities of paid employment and child rearing Social and cultural phenomenon- Social: Rests upon social practices (key structure of retirement) Cultural: Given symbolic meaning Varied experiences of ageing process, older people as active citizens and consumers?
36
What is ii) The challenge of individualisation?
Social identity less of a ‘given’ and more of a ‘task’ to be achieved – the individual is charged with ‘the responsibility for performing that task and for the consequences (also the side-effects) of their performance'
37
What is the iii) fourth age?
Social imaginary – ‘a set of unstated but powerful assumptions concerning the dependencies and indignities of ‘real’ old age’ Meanings attributed to ageing bodies: > Fourth age can appear to be ‘nothing but the body’ > Beauty work and distancing processes to avoid appearing ‘old’
38
what is 4. Critical gerontology theory?
Critiquing and changing society Three main areas - Structural pressures and constraints - Meaning - Empowerment Ageing as socially constructed! Ageing negotiated by the individual, but considering the role of economic and political systems in shaping power arrangements and inequalities.
39
What are life stories?
Biographically informed approach to thinking about older age. - Interview transcripts
40
List some Demographic Population Changes
- Increase in numbers of older people - People are living longer - Medical intervention & treatment - Better social conditions - Improvements in public health - Women living longer than men - Baby boomers of 1940’s & 1960’s
41
Describe the 'old and very old gen' in terms of their teeth (2)
Large proportion edentulous | Plastic tooth generation
42
Describe the 'entering old age' in terms of their teeth (3)
Retained much/most of their natural dentition Requires maintenance to avoid tooth loss Heavy metal generation
43
Describe the 'future old people' in terms of their teeth (4) | =Middle age and younger
Good oral health Cosmetic dentistry - White tooth generation
44
Name some Influences on Ageing:
- Genetic & environmental factors -Life-style -Effect of illness & disability -Effects of medication -Personality: Rigid/pessimistic or flexible/optimistic -Psychiatric history -Level of independence: Mobility Activities of daily living - washing, dressing, bathing, personal hygiene
45
Frail Older AdultsBarriers to Dental Care
``` Medical problems Drug interactions Ability to understand and tolerate treatment Financial Access Low expectations Acceptance of loss of function and pain ```
46
NICE Guidance 48 (on oral care of older people)
This guideline covers oral health, including dental health and daily mouth care, for adults in care homes. The aim is to maintain and improve their oral health and ensure timely access to dental treatment.
47
Frail Older Adults-Benefits of Oral Health Care
Improve eating Improve speech Improve facial appearance Decrease pain All help to reduce social isolation. Poor masticatory function may mean a poor/ restricted diet.
48
Common Oral Health Problems of old people
Tooth loss and replacement Tooth wear Collapsing/failing/terminal dentition Dry mouth due to medication Compromised self-care due to disability
49
Tooth loss and replacement- people are losing their teeth later on in life, why does this pose a greater challenge?
No previous denture wearing experience Less able to learn skills High expectations
50
What problems does Tooth Wear in older people cause? Name 5
``` Reduced face height Pulp death Sensitivity Aesthetics Sharpness to tongue Brittle Difficult extractions ```
51
Dry Mouth in older adults- what can this cause? Name 5 - due to medication/age
``` Difficulty in wearing dentures Root caries Difficulty with mastication Difficulty with speech Soreness & ulcers Lack of appetite ```
52
Problems associated with Periodontal disease?
``` Multiple abscesses Bleeding gums Mobility Pain Halitosis Aesthetics ```
53
What is Residential Oral Care in Sheffield (ROCS)?
Salaried service working jointly with GDPs in city to increase numbers of people in care homes able to access oral care
54
Problems relating to treatment and patient management increase with the age of the patient.. some examples:
- Knowing who actually needs tx - Don't usually come to dentist bc of pathology - Physically proving the tx (transport) - The dental surgery environment may be difficult for the older patient to manage - Older patients have reduced ability to adapt to change
55
Examples of pathology that may come up in older people (5)
``` Denture stomatitis Oral cancer Denture granuloma Lichen planus Oral infections ```
56
There are problems actually physically providing treatment?
- Domiciliary care? - Ambulance/meditaxi to bring in - Capability travelling alone? - Neighbours/ family?
57
What is Domiciliary dentistry
Easy for the patient but more difficult for the clinician. Chaperone necessary Take all equipment necessary including light and take all clinical waste away.
58
is the surgery suitable for the elderly? | Things to think about:
``` Access Toilets Lighting Busy environment TIME ```
59
The dental surgery environment may be difficult for the older patient to manage problems it May lead to...:
``` Confusion Lack of compliance Intolerant of long procedures Bright light Too noisy Postural problems ```
60
How to make the dental experience easier–patient management | (4)
Seating – keep upright, or slowly alter position Noise – low tones, reduce noise and speed Confusion – reduce speed, less instruction- - check medical history (GP or family) Timing of appointment – medication, capability,convenience
61
How to Help older people adapt to change with dentures–
1) Make small changes to existing dentures reline adapt existing denture 2) Copy existing dentures, having made alterations 3) Make new dentures that are similar to some aspects of previous dentures
62
Problems that actually affect treatment during stages of complete denture construction may be due to : (2)
Age | Consequences of tooth loss
63
Consequences of tooth loss affect: (4)
- impression taking, - jaw registration, - retention and stability of the denture - ability to wear the denture
64
How does Tooth loss affect alveolar resorption?
Following tooth loss, alveolar bone resorbs, rapidly at first but decreases with time After loss of the teeth the remaining alveolar bone forms the alveolar ridge - gives support to a denture - part of the denture-bearing area.
65
Where is there most bone resorp? max or mand?
Approximately 4 times as much resorption of mandible as maxilla More in mandible!!!
66
Describe the general pattern of alveolar bone resorption/loss?
Around an individual tooth, resorption is greater where the cortical plate is thinner.... i.e.: Maxilla: LOSS buccally most; MOVES LINGUALLY Mandible: (in at front, out at back) - Anterior: LOST buccally... MOVES LINGUALLY - Posterior: Buccal plate is reinforced by external oblique ridge; there is resorp of thinner lingual plate-->> movement of residual ridge => BUCCALLY!!
67
The clinical significance of alveolar resorption depends on the degree to which it occurs. e.g: (4)
Too little resorption Irregular resorption Excessive resorption Normal resorption
68
Denture problems if Too little resorption?
Too little resorption will lead to bulky alveolar ridges with little space in which to place dentures - adequate interalveolar space. - frequent denture fracture - excessive face height - Denture too big... - Compromised function to speak, eat (Size of denture is usually increased to give strength...)
69
Denture problems if Irregular resorption?
Bone may be sharp and the soft tissues may get traumatised under the denture leading to ulcers and discomfort. Surgical reduction of the ‘knife-edge’ ridge may be needed.
70
Denture problems if excessive resorption?
normal relationship of the posterior teeth may be changed? With the increase in width of the mandible posteriorly, a ‘posterior crossbite’ is produced. Anteriorly, where buccal resorption of the maxilla predominates, an edge-to-edge incisor relationship or prominent mandible may occur.
71
Denture problems if excessive resorption in mandible?
atrophy of the alveolus causes the mental foramen to become superficial (nerve?) the mylohyoid ridge on the lingual aspect of the mandible becomes sharp and prominent. Both may cause pain during denture wear.
72
Denture problems if normal resorption?
A few months after extraction resorption has taken place. The dentures start to feel loose- the dentures need relining or replacing to improve the retention.
73
Useful Clinical Techniques to Help Prosthetic Treatment
``` Check record Windowed trays Neutral Zone Impression Technique Retained roots Polycarbonate Soft Liners ```
74
What is a windowed tray?
For anterior flabby ridges An overall impression is taken in a ‘windowed’ tray constructed on a primary impression. With the impression in the mouth the ‘window’ is filled with a fluid impression material (silicone, plaster etc.).
75
Use of polycarbonate?
To reduce likelihood of midline fracture
76
What is Soft liner?
More comfortable base over irregular ridges Processed onto denture in laboratory. Lasts 6/12 – 3 years.
77
Oral surgery examples(may be the option for difficult prosthetics cases)
Implants Sulcus deepening Ridge augmentation