**_💊Pharmacology💊 - Pharmacodynamics & Pharmacokinetics Flashcards
What is the difference between pharmacology and therapeutics?
Pharmacology is the study of drug action, how a drug interacts with living organisms and how this influences physiological function
Therapeutics is concerned with drug prescribing and the treatment of disease, more focused on the ‘patient’
What is the difference between pharmacodynamics and pharmacokinetics?
Pharmacodynamics deals with ‘what the drug does to the body’ and pharmacokinetics deals with ‘what the body does to the drug’
What 3 things must be considered when evaluating the effect a drug has on the body?
Where is the effect produced?
What is the target for the drug?
What is the response that is produced after interaction with this target?
What must a drug do in order to have an effect?
Be bound to a target
Are drugs often limited to just 1 effect on the body?
No!
What effect does cocaine have?
Produces a euphoric high
Also, can be an effective local anaesthetic
Where in the body is the euphoric effect produced by cocaine?
The nucleus accumbens
What is the specific cellular target of cocaine?
Dopaminergic neurones in the nucleus accumbens
What is the specific molecular target of cocaine?
The dopamine reuptake protein on the pre-synaptic terminal of dopaminergic neurones
What is the response that is produced after cocaine’s interaction with it’s target?
Cocaine will BLOCK the dopamine reuptake protein. This means that dopamine is not removed from the synapse as quickly, and is thus more available to bind to the dopamine (D1) receptor. Activation of this receptor is what causes euphoria
What are the 4 different types of drug targets?
Receptors
Enzymes
Ion channels
Transport proteins
What type of target does aspirin bind to?
Enzyme
What is the effect of aspirin?
Aspirin binds to the ‘enzyme’ cyclooxygenase and blocks the production of prostaglandins
What type of target do local anaesthetics bind to?
Ion channels
What is the effect of local anaesthetics?
Local anaesthetics block sodium ‘ion channels’ and thus prevent nerve conduction
What is the target of Prozac (anti-depressant)?
Carrier proteins
What is the effect of Prozac?
Prozac (Anti-depressant) block serotonin ‘carrier proteins’ and prevent serotonin being removed from the synapse
What is the target of nicotine?
Receptor
What is the effect of nicotine?
Nicotine binds to and activates the nicotinic acetylcholine ‘receptor’
Why is selectivity important for a drug?
So that it only effects the desired target
Minimal side and adverse effects