9: Treatment Options Flashcards
T/F Some chemotherapy drugs are considered chemo only when used in combination with other drugs.
True. For example, dexamethasone is chemo when combined with velcade and cytoxan for multiple myeloma.
Which stage of the cell cycle: G0, G1, S, G2, or M?
Mitosis (cell splits into 2).
M
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Adriamycin, Bleomycin.
Antitumor antibiotics
Photon or particle ionizing radiation?
Protons
Particle (ionizing) radiation
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Stop mitosis or inhibit enzymes from making proteins required for cell reproduction.
Mitotic inhibitors
T/F Watchful waiting can make some patients uncomfortable, but some cancers may not require therapy for years.
True. Chronic lymphocytic leukemia you monitor in the WBC. May not require treatment for years.
Which stage of the cell cycle: G0, G1, S, G2, or M?
Apparatus for mitosis is built.
G2
Which stage of the cell cycle: G0, G1, S, G2, or M?
RNA and protein synthesis are made for dividing.
G1
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Interfere with enzymes called topoisomerases (help separate strands of DNA for replication).
Topoisomerase inhibitors
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Taxol, Taxotere, Vincristine
Mitotic inhibitors
T/F Radiation effects can linger for decades.
True. Uncommon, but can increase secondary malignancies or cause idiopathic pulmonary fibrosis, for example.
Photon or particle ionizing radiation?
Electrons
Particle (ionizing) radiation
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Irontecan, Etoposide
Topoisomerase inhibitors
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Cytoxan, Cisplatin, platinum-based therapies.
Alkylating agents
Photon or particle ionizing radiation?
Neutrons
Particle (ionizing) radiation
_____ is hormone therapy used to treat prostate cancer.
Lupron
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
5-FU, Pemetrexed
Antimetabolites
Which stage of the cell cycle: G0, G1, S, G2, or M?
DNA synthesis.
S
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Interfere with DNA and RNA growth, specifically during S phase.
Antimetabolites
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Commonly used to treat ovarian cancer.
Alkylating agents
Photon or particle ionizing radiation?
Gamma rays
Photon (ionizing) radiation
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Can cause neuropathy.
Alkylating agents
Cancer management (4).
- Watchful waiting
- Chemo
- Radiation
- Surgery
Photon or particle ionizing radiation?
Most widely used in cancer treatment.
Photon (ionizing) radiation
Photon or particle ionizing radiation?
X-rays
Photon (ionizing) radiation
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Directly damage DNA and prevent cancer cells from reproducing and growing.
Alkylating agents
T/F Debulking surgery is common for most solid tumors.
True. It can help relieve symptoms.
Which stage of the cell cycle: G0, G1, S, G2, or M?
Cell rests from dividing and does its normal physiologic work.
G0
Tarceva targets the _____ mutation in lung cancer patients.
EGFR
During which cell cycle is radiation least effective?
G0 (slowly dividing)
Alkylating agents, antimetabolites, antitumor antibiotics, topoisomerase inhibitors, or mitotic inhibitors?
Interfere with enzymes involved in DNA replication.
Antitumor antibiotics
