9: Myopathies Flashcards
1
Q
What are common myopathy signs?
A
Stiffness and reluctance to mvoe
2
Q
Why do many myopathies look similar?
A
Skeletal muscle has a limited pathological response
3
Q
Where is CK produced?
A
Skeletal and cardiac muscle
4
Q
After how long does CK peak?
A
4-6 hours and then cleared in days
5
Q
Where is AST produced?
A
Skeletal and cardiac muscle, liver, RBCs etc
6
Q
After how long does AST peak?
A
12-24 hours and cleared in 2-3 weeks
7
Q
How can you diagnose a myopathy?
A
Submaximal exercise test and take blood samples pre-exercise and 4-6 hours later
8
Q
What degree of CK rise suggests a sub-clinical exertional myopathy?
A
2-3x
9
Q
How can you differentiate trauma and fibrosis?
A
Ultrasound
