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Immunology > 9 - immunotherapy pt 2 > Flashcards

9 - immunotherapy pt 2 Flashcards

1
Q

what is the 1st line treatment for non-Hodgkin’s lymphoma?

A

rituximab

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2
Q

what is rituximab specific for?

A

Specific for the CD20 molecule on the cell surface of a small sub-population of B cells

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3
Q

what is infliximab?

A

anti-TNF therapy

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4
Q

name 4 diseases infliximab is used to treat?

A

Ankylosing spondylitis
Crohn’s disease
Ulcerative colitis
rheumatoid arthritis

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5
Q

what is herceptin AKA and what is it used to treat?

A

AKA - trastuzumab, binds to HER2 cells in breast cancer

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6
Q

how does pertuzumab differ from herceptin?

A

Pertuzumab is directed at the dimerisation domain of HER2 – disruption of dimer formation

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7
Q

what is Skyrizi AKA, target and antibody?

A

AKA - risankizumab,
target - IL-23 p19 subunit,
antibody - IgG1 humanized

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8
Q

name 3 side effects of skyrizi?

A

URTI, fungal skin infection, headache

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Immunology (9 decks)

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