8 - immunotherapy pt 1

Question 1

2 types of immunity?

Answer 1

adaptive, innate

Question 2

2 examples of adaptive (active) immunity?

Answer 2

infection/ exposure, immunisation vaccines

Question 3

3 examples of innate (passive) immunity?

Answer 3

placental transfer of IgG, colostral transfer of IgA, immunoglobulin therapy

Question 4

active immunity - specificity/ memory?

Answer 4

specificity - yes, memory - yes

Question 5

passive immunity - specificity/ memory?

Answer 5

specificity - yes, memory - NO

Question 6

example of passive immunity?

Answer 6

snake bite

Question 7

HNIG - name 4 conditions?

Answer 7

Hepatitis A, Measles, Polio, Rubella

Question 8

specific immunoglobulins - name 4 conditions?

Answer 8

Hepatitis B, Rabies, Tetanus, Varicella-Zoster Virus

Question 9

what is IV immunoglobulin?

Answer 9

a biologic for primary and secondary Immune deficiencies, along with autoimmune disorders

Question 10

how else can polyclonal IgG be taken )other than IVIg?

Answer 10

SCIg - sub-cutanaeously

Question 11

what is the dose for IVIg?

Answer 11

1-3g/kG

Question 12

name 4 licensed indications for IVIg?

Answer 12

1y immunodeficiency, Wiskott Aldrich syndrome, idiopathic thrombocytopenic purpura, kawasaki disease

Question 13

2 different types of immunotherpay?

Answer 13

direct (targeted) and indirect

Question 14

what is the target in direct immunotherapy?

Answer 14

the tumour

Question 15

what is the target in indirect immunotherapy?

Answer 15

the immune system

Question 16

give 3 examples of direct immunotherapy?

Answer 16

monoclonal antibodies, CARs, bi-specific antibodies

Question 17

give 3 examples of indirect immunotherapy?

Answer 17

tumour vaccines, dendritic cell vaccines, checkpoint inhibitor therapies

Question 18

what is Pegylated and what is it used for?

Answer 18

an anti-viral IFN-alpha therapy - used in melanoma