9 - Gingival Overgrowth

Question 1

9. 15 Phenytoin Sodium (Dilantin)
   - What percent incidence?
   - Generally begins how many months?
   - Initial lesion involves ___
   - Positive correlation with inadequate ___
   - T/F: Incidence/severity of gingival enlargement has correlation with dosage, plasma levels, and duration
   - Although rare, Dilantin gingival enlargements may occur in what two types of patients?

Answer 1

1. 50%
2. 1-3 months
3. Gingival papillae
4. Oral hygiene
5. False - no correlation
6. Edentulous mouths and under pontics/partial dentures

Question 2

9. 16 Percentages
   - Carbamazepine
   - Phenytoin Sodium
   - Phenytoin Sodium + Sodium Valporate
   - Phenytoin Sodium + Carbamezipine
   - Phenytoin Sodium + Carbamazapine + Phenobarbital

Answer 2

1. 0%
2. 52%
3. 56%
4. 71%
5. 83%

Question 3

9. 33 What is the histology of Nifedipine/Cyclosporine hyperplasia?
   - Epithelial rete ridges?
   - Collagen composition?
   - Production levels of matrix macromolecules by fibroblasts?

Answer 3

1. Elongated epithelial rete ridges
2. Normal collagen composition
3. Increased production

(Probably don’t have to know this)