9. General Anesthesia Flashcards
What are the stages of General anesthesia
Stage I= Analgesia
-From induction to loss of conciousness
Stage II= Stage of excitement
- From loss of conciousness to automatic breathing
- Breath-holding
- Vomiting
- Irregular respiration
Stage III= Surgical anesthesia (onset of automatic breathing to respiratory paralysis)
- Plane 1= From automatic breathing to loss of eye movement
- Plane 2= From loss of eye movement to partial paralysis of intercostal mm
- Plane 3= Complete paralysis of intercostal muscles
- Plane 4= Paralysis of the diaphragm
Advantages of General Anesthesia
- No need for LA
- Control over respiration and heart function
- Reduces awarness and recall
- Easily adaptable and rapidly administered and reversible
Disadvantages of GA
- Cost
- Pre-op patient management (need to be NPO)
- Requires increased complexity of care
- Malignant hyperthermia**
- NV, sore throat, nose bleed, headache
- Delayed return to normal mental function
What are the CNS effects of volatile anesthetics
- Changes in cognition recovery time= 24-36 hrs
- Psychomotor recovery= 24-36 hrs
- JAMA pediatrics kids that have had GA have less than 1/2% lower GPAs than kids that didn’t have GA
According to the FDA GA should be done for kids under the age of _ and for what other patient population
<3 y.o
-Pregnant (3rd trimester)
Respiratory effects of volatile anesthetics
- Increased PaCO2
- Decreased response to increase PaCO2 (central chemoreceptors)
- Deminished response to PaO2(peripheral chemoreceptors)
- Decreased tidal volume
- Increased respiration rate
- Net decrease in airway resistance (block effects of histamine)
- Apnea produced with greater depths
Volatile anesthetics result in lose of which muscles first? Diaphragm or intercostal
-intercostal
CV effects of volatile anesthetics
- Decreased arterial BP= decreased peripheral resistance and cardiac output
- Decrease O2 needs of the heart
- Reflex stimulation of SNS
- Sensitizes the myocardium to catecholamines (esp. halothane) –> cardiac dysrhythmias
For volatile anesthetics blood flow decreases to what organs and increases to what organs
Decreases
- Kidney
- Liver
- Gut
Increases
- Brain
- Muscle
- Skin
Renal effects of volatile anesthetics
decreased GFP and decrease in urine output
Endocrine effects of volatile anesthetics
- Not much effect with sevofluorane
- Decreased insulin secretion and tissue response to insulin
- Decreased testosterone
Neuromuscular effects of volatile anesthetics
-Muscle relaxation
Toxicities of volatile anesthetics
- Renal toxicity (metabolism of fluoride ions from halogenated hydrocarbons)
- Hepatotoxic (necrosis) -esp halothane
- Malignant hyperthermia
What is Malignant hyperthermia
-Ca2+ binds myosin and does dissociate –> chronic muscle contraction
Consequences of malignant hyperthermia
- -Constant muscle contraction (rigidity)
- Electrolyte imbalance
- Increased PaCO2
- Respiratory and metabolic acidosis
- Tachycardia