9 | Article: Tiwari et al. (2021): Reproducibility in Systems Biology modelling Flashcards

1
Q

Name two common reasons why computational models fail to be reproducible.

(2022_2)

A
  • missing parameter values
  • missing initial conditions
  • inconsistency in model structure
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2
Q

Give two suggestions what to change in the Hoffmann et al. (2002) article to improve its reproducibility.

(2022_2)

A
  • share model codes for mathematical expression and simulation publicly ideally:
    • well and unambiguously documented,
    • in a standard format eg SBML,
    • in an open model database.
    • semantically enriched with annotations
  • share numerical results publicly along with model codes
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